Results 61 to 70 of about 49,496 (354)

Differences between Dorsal Root and Trigeminal Ganglion Nociceptors in Mice Revealed by Translational Profiling

Journal of Neuroscience, 2019
Nociceptors located in the trigeminal ganglion (TG) and DRG are the primary sensors of damaging or potentially damaging stimuli for the head and body, respectively, and are key drivers of chronic pain states. While nociceptors in these two tissues show a
S. Megat, P. Ray, Diana Tavares-Ferreira, J. Moy, Ishwarya Sankaranarayanan, Andi Wanghzou, Tzu Fang Lou, P. Barragán-Iglesias, Z. Campbell, G. Dussor, Theodore John Price   +10 more
semanticscholar   +1 more source

Characterization of two Runx1-dependent nociceptor differentiation programs necessary for inflammatory versus neuropathic pain

Molecular Pain, 2010
Background The cellular and molecular programs that control specific types of pain are poorly understood. We reported previously that the runt domain transcription factor Runx1 is initially expressed in most nociceptors and controls sensory neuron ...
Arber Silvia, Kramer Ina, Yang Fu-Chia, Liu Yang, Samad Omar, Ma Qiufu   +5 more
doaj   +1 more source

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

Fremanezumab—A Humanized Monoclonal Anti-CGRP Antibody—Inhibits Thinly Myelinated (Aδ) But Not Unmyelinated (C) Meningeal Nociceptors

Journal of Neuroscience, 2017
Calcitonin gene-related peptide (CGRP), the most abundant neuropeptide in primary afferent sensory neurons, is strongly implicated in the pathophysiology of migraine headache, but its role in migraine is still equivocal.
A. Melo-Carrillo, A. Strassman, R. Nir, Aaron J. Schain, R. Noseda, Jennifer Stratton, R. Burstein   +6 more
semanticscholar   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Innate Receptors Expression by Lung Nociceptors: Impact on COVID-19 and Aging

Frontiers in Immunology, 2021
The lungs are constantly exposed to non-sterile air which carries harmful threats, such as particles and pathogens. Nonetheless, this organ is equipped with fast and efficient mechanisms to eliminate these threats from the airways as well as prevent ...
Carlos H. Hiroki, Carlos H. Hiroki, Nicole Sarden, Nicole Sarden, Mortaza F. Hassanabad, Mortaza F. Hassanabad, Bryan G. Yipp, Bryan G. Yipp   +7 more
doaj   +1 more source

Maximum axonal following frequency separates classes of cutaneous unmyelinated nociceptors in the pig

Journal of Physiology, 2020
C‐nociceptors are generally assumed to have a low maximum discharge frequency of 10–30 Hz. However, only mechano‐insensitive ‘silent’ C‐nociceptors cannot follow electrical stimulation at 5 Hz (75 pulses) whereas polymodal C‐nociceptors in the pig follow
Fiona Werland, Michael Hirth, R. Rukwied, M. Ringkamp, B. Turnquist, E. Jørum, B. Namer, M. Schmelz, O. Obreja   +8 more
semanticscholar   +1 more source

Lead‐Free Bismuth Halide Perovskite Memristors: Low‐Voltage Switching and Physical Modeling of Resistive Hysteresis

Advanced Materials Technologies, EarlyView.
Lead‐free bismuth halide perovskite memristors exhibit stable low‐voltage resistive switching behavior. The conductance‐activated quasi‐linear memristor model quantitatively reproduces the experimental hysteresis, confirming ion migration‐driven filament dynamics.
So‐Yeon Kim, Gonzalo Rivera‐Sierra, Bitania Shiferaw Mengesha, Benjamin Iniguez, Juan Bisquert   +4 more
wiley   +1 more source

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]

, 2007
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B, Bowden, S, Brust, A, Cesare, P, Colless, B, Drew, LJ, Gale, JE, Heinzmann, S, Lewis, RJ, Robinson, M, Rugiero, F, Wood, JN   +11 more
core  

Loss of μ-opioid receptor signaling in nociceptors, and not spinal microglia, abrogates morphine tolerance without disrupting analgesic efficacy

Nature Medicine, 2016
Opioid pain medications have detrimental side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). Tolerance and OIH counteract opioid analgesia and drive dose escalation.
G. Corder, V. Tawfik, Dong Wang, Elizabeth I Sypek, Sarah A. Low, Jasmine R Dickinson, Chaudy Sotoudeh, J David Clark, B. Barres, Christopher J. Bohlen, G. Scherrer   +10 more
semanticscholar   +1 more source