Myofascial Pain Syndrome: A Nociceptive Condition Comorbid with Neuropathic or Nociplastic Pain [PDF]
Life, 2023 Myofascial pain syndrome is featured by the presence of myofascial trigger points (TrPs). Whether TrPs are primary or secondary phenomena or if they relate to central or peripheral nervous system disorders is controversial. Referred pain, a cardinal sign
César Fernández-de-las-Peñas +6 more
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Pathophysiology of Nociplastic Pain
AAO JournalNociplastic pain represents a category of pain not directly linked to tissue damage or neuropathic conditions. It involves abnormal processing of pain signals by the central nervous system, often leading to symptoms like allodynia and hyperalgesia.
Roberto Tedeschi
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Can Myofascial Trigger Points Involve Nociplastic Pain? A Scoping Review on Animal Models [PDF]
Journal of Pain Research, 2023 Wiktoria Matuska,1 Jakub Matuska,2 Elżbieta Skorupska,2 Maria Siwek,3 Pablo Herrero,4 Manel M Santafé5 1Faculty of Veterinary Medicine and Animal Science, University of Life Sciences, Poznań, Poland; 2Department of Physiotherapy, University ...
Matuska W +5 more
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Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice
Neurobiology of Pain, 2023 Nociplastic pain, the most recently proposed mechanistic descriptor of chronic pain, is the pain resulting from an altered nociceptive system and network without clear evidence of nociceptor activation, injury or disease in the somatosensory system.
Manami Yajima +3 more
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Nociplastic Pain in Gynecology: Understanding This Painful Experience in Women
, 2023 The term “nociplastic pain” was introduced in 2017 by the International Association for the Study of Pain (IASP) to describe pain that results from impaired nociception despite no clear evidence of actual or potential tissue damage causing activation of peripheral nociceptors or evidence of disease or lesion of the somatosensory system causing the pain.
Lucia Merlino +6 more
openaire +3 more sources
Early life social isolation stress and pain vulnerability: unraveling neuroimmune mechanisms and central sensitization [PDF]
Frontiers in PharmacologyChronic pain is increasingly recognized as a multidimensional condition in which neuroimmune interactions shape disease vulnerability and persistence.
Carmela Belardo +15 more
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Landau model for illustrating the learning and unlearning process of nociplastic pain
Frontiers in Pain ResearchRecent advancements in understanding the consolidation of nociplastic pain point to a complex, non-conscious learned process of threat perception. Neurobiological pain education is emerging as a promising approach to unlearn nociplastic pain, supported ...
Belén Valenzuela
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Breaking the medication overuse headache cycle: from nociplastic pain mechanisms to patient-centered interventions — the Junior Editorial Board vision [PDF]
The Journal of Headache and PainBackground Medication-overuse headache (MOH) is a prevalent and disabling secondary headache disorder that arises in individuals with a pre-existing primary headache as a consequence of regular overuse of acute medications.
Roberta Messina +10 more
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The concept of nociplastic pain—where to from here?
PainAbstract Nociplastic pain, a third mechanistic pain descriptor in addition to nociceptive and neuropathic pain, was adopted in 2017 by the International Association for the Study of Pain (IASP). It is defined as “pain that arises from altered nociception” not fully explained by nociceptive or neuropathic pain mechanisms.
Kosek, Eva,, Kosek, E,
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Male-specific mechanisms in a murine model of nociplastic pain [PDF]
, 2022 In order to address how acute nociceptive pain can transition to nociplastic pain, we developed a murine model in which acute injury-induced mechanical hypersensitivity was prolonged beyond its normal resolution time following postinjury stimulation at ...
McDonough, Kathleen Erin
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