Results 61 to 70 of about 1,002,831 (175)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Neuropathic pain in cerebral palsy and related genetic conditions: A scoping review of prevalence, characteristics, and management

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To map existing evidence on neuropathic pain in cerebral palsy (CP) and related genetic conditions, including prevalence, descriptors, assessment methods, and management. Method Following prospective registration, five databases (Ovid MEDLINE, Embase, CINAHL, Web of Science, Google Scholar) were searched in June 2025.
Aayushi Khillan, Sanya Verma, Hannah Yeomans, Karen Bau, Caitlin Doyle, Monica S. Cooper, David J. Amor, Carolyn Berryman, Adrienne Harvey   +8 more
wiley   +1 more source

Can we achieve pain stratification in musculoskeletal conditions? Implications for clinical practice

Frontiers in Pain Research
In the last few years there has been an increased appreciation that pain perception in rheumatic and musculoskeletal diseases (RMDs) has several mechanisms which include nociceptive, inflammatory, nociplastic and neuropathic components.
Nidhi Sofat, Nidhi Sofat, Andrew Lambarth, Andrew Lambarth   +3 more
doaj   +1 more source

Physical activity level and physical fitness in subjects with chronic musculoskeletal pain: a cross-sectional study [PDF]

PeerJ
Background Low physical activity (PA) levels and low physical fitness (PF) have been reported in subjects with temporality-based chronic pain; however, it is unknown whether there are differences in subjects with nociplastic pain (NP) compared with ...
Gabriel Rojas, Ignacio Orozco-Chavez
doaj   +2 more sources

Transcranial electric stimulation in chronic pain: Effects on quality of life, physical function, activity and clinical status

Journal of Neuropsychology, EarlyView.
Abstract Transcranial electric stimulation represents a promising non‐invasive neuromodulatory technique targeting maladaptive nociplastic changes in chronic pain (CP) with analgesic effects. However, its impact beyond pain reduction on broader outcomes such as quality of life (QoL) and physical function remains unclear.
Antonio Gil‐Ugidos, María López‐Corchón, Gavriella Τsiarleston, Víctor Segura‐Jiménez, María Teresa Carrillo‐de‐la‐Peña   +4 more
wiley   +1 more source

Effects of Aerobic Exercise and Strength Training on Nociplastic Pain and Clinical Features in Temporomandibular Disorders With Myalgia: A Randomized‐Controlled Trial

Journal of Oral Rehabilitation, EarlyView.
In this randomized controlled trial, adding aerobic exercise or strength training to physical therapy improved outcomes in patients with temporomandibular disorders and nociplastic pain. Aerobic exercise produced greater reductions in pain and central sensitization‐related symptoms, whereas strength training improved trapezius muscle strength and long ...
Flora Dantony, Daniel Romero‐Rodríguez, David Blanco, Carlos Antonio Zárate‐Tejero, Carolina Climent‐Sanz, Cristina Pérez‐Mánen, Andrea Màcia‐Martí, Natalia Felipe‐Spada, Andoni Carrasco‐Uribarren   +8 more
wiley   +1 more source

Biofeedback‐Based Therapy in Patients With Myofascial Orofacial Pain and Bruxism: An Umbrella Review

Journal of Oral Rehabilitation, EarlyView.
This umbrella review of 11 systematic reviews found that biofeedback may reduce masticatory muscle activity, but its effects on myofascial orofacial pain and bruxism remain uncertain. Methodological limitations, heterogeneous protocols, and predominantly low‐quality evidence underscore the need for rigorous, standardized clinical trials.
Celine Beriger, Kathrin Kohout, Aleksandra Zumbrunn, Edwin Ruales‐Carrera, Tan Fırat Eyüboğlu, Mutlu Özcan   +5 more
wiley   +1 more source

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

MedComm
Chronic pain imposes incalculable health and economic burdens, affecting more than 30% of the global population in published studies. Optimal management of chronic pain is imperative for individuals experiencing such distress.
Zhen Li, Xing Li, Jieqiong Liu, Rao Sun, Yingze Ye, Hongbing Xiang, Fang Luo, Shiyong Li, Ailin Luo   +8 more
doaj   +1 more source

Characterizing Jaw Pain After Traumatic Brain Injury: A Case Control Study

Journal of Oral Rehabilitation, EarlyView.
This secondary analysis of a case–control study of 121 participants with TBI and 118 participants without TBI demonstrates that jaw pain is significantly more prevalent among participants with a history of TBI compared to those without TBI.
Talia B. Just, Donald R. Nixdorf, Michael D. Evans, Shanti Kaimal, David P. Darrow, Dawn Neumann   +5 more
wiley   +1 more source