Results 71 to 80 of about 1,002,831 (175)

Pain variability in nociplastic pain conditions

This systematic review aims to investigate current quantitative evidence of intra-individual pain variability in nociplastic chronic pain conditions in adults.
Karin Jensen, Valentina Molinari, Julie Klinke   +2 more
core   +1 more source

Pregabalin and Duloxetine in Patients with Non-Nociceptive Pain: A Narrative Review Exploring the Pharmacological Effects of This Combination

Pharmaceuticals
Both neuropathic and nociplastic pain (non-nociceptive pain) are characterized by a similar pattern of clinical symptoms, including numbness, dysesthesia, tingling, and pricking.
Gianmarco Marcianò, Maurizio Evangelista, Cristina Vocca, Vincenzo Rania, Caterina Palleria, Maria Cristina Caroleo, Riccardo Torta, Luca Gallelli   +7 more
doaj   +1 more source

Distinct effects of fibromyalgia pain, depression and anxiety on perception of affective touch and pain

The Journal of Physiology, EarlyView.
Abstract figure legend Patients with fibromyalgia (FM) and no‐pain controls completed questionnaire‐based ratings of chronic pain, childhood trauma, anxiety and depression. Brief touch stimuli were then administered, including slow brushing at the C‐tactile optimal velocity of 3 cm/s, deep oscillating pressure with a compression sleeve, roboticized ...
Benedetta Albinni, Marisa Zimmerman, Vincent Alasha, Jacob Ross, Lindsey Crankshaw, Sandy R. Hu, Nathaniel Schuster, Laura Case   +7 more
wiley   +1 more source

Central Nervous System Mechanisms and Treatment Response in Chronic Ocular Surface Pain: Protocol for a Cross-Sectional Observational Phenotyping Study

JMIR Research Protocols
BackgroundChronic ocular surface pain (COSP), occurring either in isolation or as part of numerous ocular conditions, such as dry eye syndrome, is a leading cause of eye care visits in the United States.
Lindsey B De Lott, Steven E Harte, Chelsea Kaplan, David A Williams, Roni Shtein, Maria A Woodward, Alexander Tsodikov, Tatiana Deveney, Anat Galor, Anne Shea, Charles Schultz, Clare McKolay, Kathy A Scott, Daniel J Clauw   +13 more
doaj   +1 more source

Disability, Fatigue and Mental Health in Acute Versus Chronic Spinal Pain in the Gaza Strip: A Comparative Cross‐Sectional Study

Musculoskeletal Care, Volume 24, Issue 4, December 2026.
ABSTRACT Background Spinal pain is a major contributor to disability, but evidence comparing multidomain outcomes across acute and chronic stages remains limited in conflict‐affected settings. This study aimed to compare disability, fatigue, psychological distress and sleep disturbance among patients with acute and chronic neck pain and low back pain ...
Marwa Salama, Ahmed A. Najim, Magdy Shabana, Reham Almukbel, Kinan Mokbel   +4 more
wiley   +1 more source

Association of Vitamin B6 and Homocysteine–ACTH Coupling With Depressive and Anxiety Symptoms in Burning Mouth Syndrome: An Exploratory Case–Control Study

Journal of Oral Rehabilitation, Volume 53, Issue 11, Page 2053-2063, November 2026.
In this exploratory case–control study, plasma PLP (vitamin B6), homocysteine and ACTH concentrations did not differ between patients with burning mouth syndrome (BMS) and controls, and none discriminated patients individually. Within patients, however, psychological distress mapped onto a homocysteine–ACTH relationship from which PLP appeared ...
Ashley Lebel, Charlotte Guillouet, André Porporatti, Yves Boucher   +3 more
wiley   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3333-3353, October 2026.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Network and cluster analyses reveal the central role of disability and the presence of nociplastic pain features in cervical radiculopathy

Cervical radiculopathy (CR) is a neuropathic condition characterized by heterogeneous clinical presentations affecting musculoskeletal, neurological, and psychological domains. The variable success of CR management may result from a limited consideration
Devecchi, Valter, Dedering, Asa, Peolsson, Anneli, Falla, Deborah   +3 more
core   +1 more source

A Multimodal Examination of Functional Brain and Neurochemical Mechanisms Underlying Nociplastic Pain

, 2022
Chronic pain affects well-being, causes suffering, and is a major burden to society. Unfortunately, pain management in the U.S. remains poor, primarily due to a lack of understanding of neurobiological mechanisms underlying pain.
Mawla, Ishtiaq
core   +1 more source

Intraindividual pain variability in chronic pain: A systematic review

Molecular Pain
Objective: To present the first systematic review on the empirical evidence for variations in intraindividual pain intensity in patients with long-term pain conditions.
Julie Klinke, Valentina Molinari, Karin Jensen   +2 more
doaj   +1 more source