Results 91 to 100 of about 140,847 (256)

Bifidobacteria and lactobacilli in the gut microbiome of children with non-alcoholic fatty liver disease: which strains act as health players? [PDF]

, 2018
Introduction: Non-alcoholic fatty liver disease (NAFLD), considered the leading cause of chronic liver disease in children, can often progress from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH).
Alisi, A, Chierico, Fd, Cucchiara, S, Drago, Lorenzo, Mosca, A, Nobili, V, Putignani, L, Stronati, L, Toscano, M, Vernocchi, P   +9 more
core   +3 more sources

Asprosin‐FABP5 Interaction Modulates Mitochondrial Fatty Acid Oxidation through PPARα Contributing to MASLD Development

Advanced Science, EarlyView.
Aided by FABP5, abnormally elevated asprosin in hepatocytes enters the nucleus, targets and inhibits PPARα binding to the CPT1A promoter, thereby suppressing FAO. Circulating asprosin exacerbates insulin resistance, collectively driving MASLD progression.
Yuan‐Yuan Yu, Min Feng, Yi Chen, Hong‐Lin Jia, Qi Zhang, Ming Tong, Yan‐Xi Li, Yu Zhao, Xin‐Xin Liu, Shi‐Feng Cao, Zheng‐kai Wang, Hou‐wei Li, Xue Liu, Yan Zhang   +13 more
wiley   +1 more source

An Off‐the‐Shelf Artificial Proregenerative Macrophage for Pressure Ulcer Treatment

Advanced Science, EarlyView.
Artificial macrophages (artM) by encapsulating M2 lysates into biodegradable PLGA microspheres and coated with macrophage membrane, are engineered as new therapeutics against skin pressure ulcer. In mouse models, the artM exhibited robust tissue repair through cell recruitment and microenvironment modulation, showing great therapeutic potential for ...
Qi Su, Jingrong Wang, Yini Huangfu, Rui Gao, Pengxu Kong, Yu Gao, Huijuan Song, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Zujian Feng, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Apoptosis and non-alcoholic fatty liver diseases

World Journal of Gastroenterology, 2018
The number of patients with nonalcoholic fatty liver diseases (NAFLD) including nonalcoholic steatohepatitis (NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma (HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown.
Hitomi Nakamura, Hiroo Imazu, Hiroaki Yamagami, Teruhisa Higuchi, Motomi Yamazaki, Kazumichi Kuroda, Naoki Matsumoto, Hiroshi Takahashi, Tatsuo Kanda, Tomohiro Kaneko, Shunichi Matsuoka, Mariko Fujisawa, Toshikatsu Shibata, Mitsuhiko Moriyama, Masahiro Ogawa, Kazushige Nirei   +15 more
openaire   +3 more sources

Correlation of serum aspartate aminotransferase level to platelet count ratio index with non-alcoholic fatty liver disease activity score [PDF]

, 2019
In case of non-alcoholic fatty liver disease, the ratio of serum aspartate  aminotransferase (AST) level to platelet count index has been proposed as a non-invasive and readily available tool for the assessment of non-alcoholic steatohepatitis.
Alam, Shahinul, Das, Dulal Chandra, Kamal, Mohammed, Mamun-Al-Mahtab, ., Mollah, Forhadul H., Noor-E-Alam, Sheikh Mohammad   +5 more
core   +2 more sources

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi   +10 more
wiley   +1 more source

Silymarin in non alcoholic fatty liver disease

World Journal of Hepatology, 2013
This study was undertaken to evaluate the hepatic effects of silybum marianum on non alcoholic fatty liver disease (NAFLD).In 72 patients affected by NAFLD, main metabolic, hepatic and anti-inflammatory parameters were assayed after 3 mo of a restricted diet and before silymarin treatment (twice a day orally). The brightness of liver echography texture
CACCIAPUOTI, Federico, Scognamiglio A, Palumbo R, Forte R, Cacciapuoti F.   +4 more
openaire   +4 more sources

M2 Macrophage‐Derived Extracellular Vesicles Reprogram Immature Neutrophils into Anxa1hi Neutrophils to Enhance Inflamed Bone Regeneration

Advanced Science, EarlyView.
This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao, Yijia Yin, Fangyuan Shuai, Waishan Lam, Tao Zhou, Yaxin Xie, Xuesong He, Xianglong Han   +7 more
wiley   +1 more source

Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation

Advanced Science, EarlyView.
Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu, Tong Ji, Zhichao Ye, Jianing Yan, Chao Wang, Jiachen Chen, Ziyang Jin, Yongji Zhu, Xiujun Cai, Yifan Wang   +9 more
wiley   +1 more source

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source