Results 31 to 40 of about 210,904 (138)

Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq [PDF]

, 2014
Thousands of small Open Reading Frames (smORFs) with the potential to encode small peptides of fewer than 100 amino acids exist in our genomes. However, the number of smORFs actually translated, and their molecular and functional roles are still unclear.
Andrews, Arava, Basrai, Bazzini, Boerjan, Brunner, Chew, Child, Chou, Crappe, Derrien, Djakovic, Duncan, Dunn, Eden, Falth, Frith, Fritsch, Galindo, Guttman, Hanada, Hanyu-Nakamura, Hemm, Ingolia, Ingolia, Ingolia, Kastenmayer, King, Kondo, Kozak, Krogh, Kulkarni, Kumar, Ladoukakis, Lemaitre, Magny, Pauli, Pueyo, Schmidt, Schneider, Siepel, Slavoff, Smith, Tripoli, Volders, Wilson   +45 more
core   +2 more sources

Coupling Bioorthogonal Chemistries with Artificial Metabolism: Intracellular Biosynthesis of Azidohomoalanine and Its Incorporation into Recombinant Proteins

Molecules, 2014
In this paper, we present a novel, “single experiment” methodology based on genetic engineering of metabolic pathways for direct intracellular production of non-canonical amino acids from simple precursors, coupled with expanded genetic code.
Ying Ma, Hernán Biava, Roberto Contestabile, Nediljko Budisa, Martino Luigi di Salvo   +4 more
doaj   +1 more source

Genome-Wide Identification, Functional Analysis and Expression Profiling of the Aux/IAA Gene Family in Tomato [PDF]

, 2012
Auxin is a central hormone that exerts pleiotropic effects on plant growth including the development of roots, shoots, flowers and fruit. The perception and signaling of the plant hormone auxin rely on the cooperative action of several components,among
Abel, Abel, Abel, Bargmann, Carole Bassa, Chaabouni, Chaabouni, Corinne Audran-Delalande, Deng, Dharmasiri, Dharmasiri, Dreher, Eshed, Farid Regad, Finn, Hagen, Hamilton, Isabelle Mila, Jain, Jones, Kagale, Kalluri, Kepinski, Kloosterman, Leclercq, Li, Liscum, Mohamed Zouine, Mondher Bouzayen, Montgomery, Nebenführ, Oeller, Ohme-Takagi, Ottenschläger, Overvoorde, Paponov, Pirrello, Reed, Remington, Saitou, Sato, Szemenyei, Tamura, Tan, Theologis, Tiwari, Tiwari, Uehara, Ulmasov, Ulmasov, Wang, Wang, Wang, Wang, Yamamoto, Zuckerkandl   +55 more
core   +4 more sources

Detecting Repetitions and Periodicities in Proteins by Tiling the Structural Space [PDF]

, 2013
The notion of energy landscapes provides conceptual tools for understanding the complexities of protein folding and function. Energy Landscape Theory indicates that it is much easier to find sequences that satisfy the "Principle of Minimal Frustration ...
Espada, Rocío, Ferreiro, Diego U., Parra, R. Gonzalo, Sippl, Manfred J., Sánchez, Ignacio E.   +4 more
core   +2 more sources

Discovery of noncanonical translation initiation sites through mass spectrometric analysis of protein N termini [PDF]

, 2017
Translation initiation generally occurs at AUG codons in eukaryotes, although it has been shown that non-AUG or non-canonical translation initiation can also occur.
Barbhuiya, Mustafa, Eacker, Stephen, Halushka, Marc, Kim, Min-Sik, Menschaert, Gerben, Na, Chan Hyun, Overall, Christopher, Pandey, Akhilesh, Pletnikova, Olga, Troncoso, Juan, Verbruggen, Steven   +10 more
core   +1 more source

Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]

, 2017
Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura, Artusi, Ilaria, De Filippis, Vincenzo, Frasson, Roberta, Peterle, Daniele, Pontarollo, Giulia   +5 more
core   +1 more source

Combinatorial Fusion Rules to Describe Codon Assignment in the Standard Genetic Code

Life, 2020
We propose combinatorial fusion rules that describe the codon assignment in the standard genetic code simply and uniformly for all canonical amino acids. These rules become obvious if the origin of the standard genetic code is considered as a result of a
Alexander Nesterov-Mueller, Roman Popov, Hervé Seligmann   +2 more
doaj   +1 more source

A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin. [PDF]

, 2017
Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the noncanonical Wnt ...
Aznar, Nicolas, Buschman, Matthew D, Dunkel, Ying, Ear, Jason, Ghosh, Pradipta, Sun, Nina   +5 more
core   +3 more sources

Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides

Cell Reports, 2020
Summary: The bacterial cell wall is made of peptidoglycan (PG), a polymer that is essential for the maintenance of cell shape and survival. During growth, bacteria remodel their PG, releasing fragments that are predominantly re-internalized and recycled.
Sara B. Hernández, Tobias Dörr, Matthew K. Waldor, Felipe Cava   +3 more
doaj   +1 more source

Convenient Genetic Encoding of Phenylalanine Derivatives through Their α-Keto Acid Precursors

Biomolecules, 2021
The activity and function of proteins can be improved by incorporation of non-canonical amino acids (ncAAs). To avoid the tedious synthesis of a large number of chiral phenylalanine derivatives, we synthesized the corresponding phenylpyruvic acid ...
Li Liu, Bohao Wang, Sheng Li, Fengyuan Xu, Qi He, Chun Pan, Xiangdong Gao, Wenbing Yao, Xiaoda Song   +8 more
doaj   +1 more source