Results 101 to 110 of about 11,145,052 (236)

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

The Role of Different Monocyte Subsets in Progression of Coronary Atherosclerotic Lesion

Journal of Mazandaran University of Medical Sciences, 2018
Background and purpose: Circulating monocytes are divided into different subpopulations according to the expression of CD14 and CD16. In this study, we investigated the correlation between the severity of coronary artery disease (CAD) and the frequency ...
Hamideh Rahimi, Mohammad Mehdi Peyghambari, Saeid Taghiloo, Hossein Asgarian-Omran, Reza Alizadeh-Navaei, Ali Heydari, Fatemeh Gabeleh, Abolghasem Ajami   +7 more
doaj  

Сhanges of the functional phenotype of circulating monocytes during pregnancy

Медицинская иммунология
Rearrangement of the immune system during pregnancy is a strictly controlled, dynamic process in which the first and third trimesters are, respectively, pro-inflammatory, and anti-inflammatory periods.
N. G. Bukhtueva, O. Yu. Leplina, E. Ya. Shevela, M. A. Tikhonova, N. M. Pasman, A. A. Ostanin, E. R. Chernykh   +6 more
doaj   +1 more source

A Novel, Five-Marker Alternative to CD16–CD14 Gating to Identify the Three Human Monocyte Subsets

Frontiers in Immunology, 2019
Human primary monocytes are heterogeneous in terms of phenotype and function, but are sub-divided only based on CD16 and CD14 expression. CD16 expression distinguishes a subset of monocytes with highly pro-inflammatory properties from non-CD16 expressing
Siew-Min Ong, Karen Teng, Evan Newell, Hao Chen, Jinmiao Chen, Thomas Loy, Thomas Loy, Tsin-Wen Yeo, Tsin-Wen Yeo, Katja Fink, Katja Fink, Siew-Cheng Wong, Siew-Cheng Wong   +12 more
doaj   +1 more source

The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum

, 2010
Acute exercise alters the surface expression of toll-like receptors (TLRs) and HLA.DR on blood monocytes, which could transiently compromise immunity.
O’Connor, Daniel P., Florida-James, Geraint, Booth, Stephen, Spielmann, Guillaume, Simpson, Richard J., O'Connor, Daniel P, McFarlin, Brian K., Florida-James, Geraint D., McFarlin, Brian K, Simpson, Richard J   +9 more
core   +1 more source

Monocytes/macrophages express CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation [PDF]

, 2010
Introduction: Monocytes/macrophages accumulate in the rheumatoid (RA) synovium where they play a central role in inflammation and joint destruction. Identification of molecules involved in their accumulation and differentiation is important to inform ...
Buckley, Christopher, Helen Williams, Cartwright, A, John HH Williams, Andrew Filer, Schmutz, Caroline, Oliver Haworth, Filer, Andrew, Mike Salmon, Haworth, O, Buckley, Christopher D., Alison Cartwright, Christopher D Buckley, Schmutz, C, Williams, John H. H., Middleton, J, Haworth, Oliver, Buckley, CD, Williams, JH, Cartwright, Alison, Caroline Schmutz, Williams, HJ, Middleton, Jim F., Williams, Helen, Salmon, Mike, Filer, A, Salmon, M, Williams, J, Williams, H, Middleton, Jim F S, Jim Middleton   +30 more
core   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Non-classical monocytes promote neurovascular repair in cerebral small vessel disease associated with microinfarctions via CX3CR1. [PDF]

J Cereb Blood Flow Metab, 2023
Lecordier S, Menet R, Allain AS, ElAli A.   +3 more
europepmc   +1 more source