Results 81 to 90 of about 11,145,052 (236)

Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis

Scientific Reports, 2017
Monocytes/macrophages are critical in systemic and local inflammation in giant cell arteritis (GCA) and possibly in clinically overlapping polymyalgia rheumatica (PMR). Therefore, we aimed to understand the contribution of monocyte subsets and the CX3CR1-
Yannick van Sleen, Qi Wang, Kornelis S. M. van der Geest, Johanna Westra, Wayel H. Abdulahad, Peter Heeringa, Annemieke M. H. Boots, Elisabeth Brouwer   +7 more
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Effect of non-surgical periodontal therapy on CD14 + CD16+ monocyte counts in peripheral blood samples: a clinical interventional study

BMC Oral Health
Monocytes and their macrophage progeny are thought to be involved in tissue and alveolar bone destruction in periodontal disease. It has been documented that the proportion of (CD14 + CD16+) non-classical monocytes in the blood are elevated in chronic ...
Raghunanthan Jagannathan, Thodur Madapusi Balaji, Suresh Ranga Rao, Meshal Saleh Alosaimi, Shankargouda Patil, Yuliia Siurkel, Marco Cicciù, Giuseppe Minervini   +7 more
doaj   +1 more source

In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets

Proteomes, 2018
Monocytes are bone marrow-derived leukocytes that are part of the innate immune system. Monocytes are divided into three subsets: classical, intermediate and non-classical, which can be differentiated by their expression of some surface antigens, mainly ...
Víctor Segura, M. Luz Valero, Laura Cantero, Javier Muñoz, Eduardo Zarzuela, Fernando García, Kerman Aloria, Javier Beaskoetxea, Jesús M. Arizmendi, Rosana Navajas, Alberto Paradela, Paula Díez, Rosa Mª Dégano, Manuel Fuentes, Alberto Orfao, Andrés García Montero, Alba Garin-Muga, Fernando J. Corrales, Manuel M. Sánchez del Pino   +18 more
doaj   +1 more source

Gene names of 22 salmon module genes and 70 Magenta module genes in non-classical monocytes.

, 2023
Gene names of 22 salmon module genes and 70 Magenta module genes in non-classical monocytes.
Karin Mueller (579839), Joan W. Berman (10860768), Klaus Ley (8593), Mardge H. Cohen (7923182), Igho Ofotokun (4059922), Stephen Gange (15674986), Tao Wang (12008), Kathryn Anastos (119435), Alan L. Landay (7919387), Phyllis C. Tien (7923128), Jason M. Lazar (10002157), Howard N. Hodis (9338345), David B. Hanna (10649576), Yanal Ghosheh (3404441), Sonya L. Heath (11605483), Qibin Qi (172143), Erik Ehinger (13558375), Juan Lin (171491), Russell P. Tracy (7300421), Wendy J. Mack (7923125), Chenglong Liu (317596), Robert C. Kaplan (7699334)   +21 more
core   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway [PDF]

, 2002
HMGB1, a non-histone nuclear factor, acts extracellularly as a mediator of delayed endotoxin lethality, which raises the question of how a nuclear protein can reach the extracellular space.
S. Gardella, D. Ferrera, M. E. Bianchi, Anna Rubartelli, A. Rubartelli, Lavinia V Lotti, Denise Ferrera, Marco E Bianchi, Stefania Gardella, C. Andrei, Maria R Torrisi, Cristina Andrei, TORRISI, Maria Rosaria, LOTTI, Lavinia Vittoria   +13 more
core   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Subpopulations of blood monocytes in patients with generalized hypoxia

Бюллетень сибирской медицины, 2019
The aim of the work is to establish general regularities and features of differentiation of blood monocytes into 4 subpopulations in diseases associated with circulatory and respiratory hypoxia.Materials and methods.
S. P. Chumakova, M. V. Vins, O. I. Urazova, D. A. Azarova, V. M. Shipulin, A. S. Pryakhin, E. B. Bukreeva, A. A. Bulanova, A. P. Koshel, E. G. Churina, A. V. Sitnikova, N. P. Garganeeva, V. V. Novitskii   +12 more
doaj   +1 more source