Results 61 to 70 of about 11,145,052 (236)

HMG-CoA reductase inhibitors deplete circulating classical and non-classical monocytes following human heart transplantation

, 2008
Background: Monocytes mediate immune responses following solid organ transplantation via cytokine secretion and differentiation to macrophage/dendritic cell lineages.
S.M. Shaw, C.T. Leonard, Mitsidou, A., Williams, S. G., Leonard, C. T., N. Yonan, Shaw, S. M., Fildes, J. E., J.E. Fildes, K. Rogacev, S.G. Williams, Yonan, N., Rogacev, K., A. Mitsidou   +13 more
core   +1 more source

Image_1_Nr4a1-dependent non-classical monocytes are important for macrophage-mediated wound healing in the large intestine.tif

, 2023
IntroductionMacrophages play an important role in intestinal wound healing. However, the trajectories from circulating monocytes to gut macrophages are incompletely understood.MethodsTaking advantage of mice depleted for non-classical monocytes due to ...
Karin Heidbreder (14444226), Imke Atreya (6285719), Tanja M. Müller (10026137), Katrin Sommer (2215342), Kai Hildner (200756), Markus F. Neurath (6628580), Maximilian Wiendl (10670622), Sebastian Zundler (2176762)   +7 more
core   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Distinct responses of newly identified monocyte subsets to advanced gastrointestinal cancer and COVID-19

Frontiers in Immunology, 2022
Monocytes are critical cells of the immune system but their role as effectors is relatively poorly understood, as they have long been considered only as precursors of tissue macrophages or dendritic cells.
Alessandra Rigamonti, Alessandra Rigamonti, Alessandra Castagna, Marika Viatore, Federico Simone Colombo, Sara Terzoli, Clelia Peano, Clelia Peano, Federica Marchesi, Federica Marchesi, Massimo Locati, Massimo Locati   +11 more
doaj   +1 more source

Table_1_Nr4a1-dependent non-classical monocytes are important for macrophage-mediated wound healing in the large intestine.pdf

, 2023
IntroductionMacrophages play an important role in intestinal wound healing. However, the trajectories from circulating monocytes to gut macrophages are incompletely understood.MethodsTaking advantage of mice depleted for non-classical monocytes due to ...
Karin Heidbreder (14444226), Imke Atreya (6285719), Tanja M. Müller (10026137), Katrin Sommer (2215342), Kai Hildner (200756), Markus F. Neurath (6628580), Maximilian Wiendl (10670622), Sebastian Zundler (2176762)   +7 more
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Changes in monocyte subsets in volunteers who received an oral wild-type Salmonella Typhi challenge and reached typhoid diagnosis criteria

Frontiers in Immunology
An oral Controlled Human Infection Model (CHIM) with wild-type S. Typhi was re-established allowing us to explore the development of immunity. In this model, ~55% of volunteers who received the challenge reached typhoid diagnosis criteria (TD), while ~45%
Franklin R. Toapanta, Jingping Hu, Kari Ann Shirey, Paula J. Bernal, Myron M. Levine, Myron M. Levine, Thomas C. Darton, Claire S. Waddington, Andrew J. Pollard, Marcelo B. Sztein, Marcelo B. Sztein, Marcelo B. Sztein   +11 more
doaj   +1 more source

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]

, 2011
Macrophages, which are abundant in the tumour microenvironment, enhance malignancy. At metastatic sites, a distinct population of metastasis-associated macrophages promotes the extravasation, seeding and persistent growth of tumour cells.
Pollard, Jeffrey W, Zhang, Hui, Jeffrey W. Pollard, Jiufeng Li, Bin-Zhi Qian, Jinghang Zhang, Campion, Liam R, Kaiser, Elizabeth A, Liam R. Campion, Zhang, Jinghang, Snyder, Linda A, Kitamura, Takanori, Qian, Binzhi, Li, Jiufeng, Elizabeth A. Kaiser, Takanori Kitamura, Linda A. Snyder, Hui Zhang   +17 more
core   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source