Results 51 to 60 of about 11,145,052 (236)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Association of intermediate monocytes with dengue severity among the pediatric population of Odisha, India

Scientific Reports
Dengue virus (DENV) infection in children exhibits varied clinical presentations, wherein the role of monocytes is important in the innate immune response. In this study, laboratory-confirmed DENV pediatric patients (n = 120), with DENV-2 infection, were
Manoj Kumar Dash, Sagnika Samal, Shailesh Rout, Rajesh Kumar Bhola, Janeka Gartia, Ishani Saha, Chinmay Kumar Behera, Hamida Hamdi, Mahesh Chandra Sahu, Biswadeep Das   +9 more
doaj   +1 more source

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes

EMBO Molecular Medicine, 2013
We used a novel approach of cytostatically induced leucocyte depletion and subsequent reconstitution with leucocytes deprived of classical (inflammatory/Gr1hi) or non‐classical (resident/Gr1lo) monocytes to dissect their differential role in ...
Oliver Soehnlein, Maik Drechsler, Yvonne Döring, Dirk Lievens, Helene Hartwig, Klaus Kemmerich, Almudena Ortega‐Gómez, Manuela Mandl, Santosh Vijayan, Delia Projahn, Christoph D. Garlichs, Rory R. Koenen, Mihail Hristov, Esther Lutgens, Alma Zernecke, Christian Weber   +15 more
doaj   +1 more source

Subgroups of monocytes predict cardiovascular events in patients with coronary heart disease. The PHAMOS trial (Prospective Halle Monocytes Study)What this paper addsWhat is known about this topic

Hellenic Journal of Cardiology, 2019
Background: Monocytes can be differentiated by the presence of CD14 and CD16 (CD14++CD16-, classical; CD14++CD16+, intermediate and CD14 + CD16++, non-classical monocytes). Recent studies have reported conflicting results regarding an association between
Florian Höpfner, Marrit Jacob, Christof Ulrich, Martin Russ, Andreas Simm, Rolf E. Silber, Matthias Girndt, Michel Noutsias, Karl Werdan, Axel Schlitt   +9 more
doaj   +1 more source

Epigenetics in non-classical monocytes support their pro-inflammatory gene expression.

, 2020
Non-classical human monocytes are characterized by high-level expression of cytokines like TNF, but the mechanisms involved are elusive. We have identified miRNAs and CpG-methylation sites that are unique to non-classical monocytes, defined via CD14 and ...
Hofer, T.P., Ziegler-Heitbrock, L., Heine, G., Zawada, A.M., Devaux, Y., Zhang, L., Krezdorn, N., Nößner, E., Rotter, B.   +8 more
core   +1 more source

Image_2_Nr4a1-dependent non-classical monocytes are important for macrophage-mediated wound healing in the large intestine.tif

, 2023
IntroductionMacrophages play an important role in intestinal wound healing. However, the trajectories from circulating monocytes to gut macrophages are incompletely understood.MethodsTaking advantage of mice depleted for non-classical monocytes due to ...
Karin Heidbreder (14444226), Imke Atreya (6285719), Tanja M. Müller (10026137), Katrin Sommer (2215342), Kai Hildner (200756), Markus F. Neurath (6628580), Maximilian Wiendl (10670622), Sebastian Zundler (2176762)   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Decrease in non-classical monocytes in Myasthenia Gravis patients

, 2022
International audienceCirculating monocytes are mononuclear cells which are highly specialized in phagocytosis and antigen presentation, secrete a large range of different cytokines, and migrate to the tissues in response to infection and injury ...
Le Panse, Rozen, Verdier, Julien, Berrih-Aknin, Sonia, Truffault, Frédérique, Demeret, Sophie, Hemery, Edouard   +5 more
core  

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source