Results 31 to 40 of about 71,540 (227)

Phenotype, function, and differentiation potential of human monocyte subsets. [PDF]

PLoS ONE, 2017
Human monocytes have been grouped into classical (CD14++CD16-), non-classical (CD14dimCD16++), and intermediate (CD14++CD16+) subsets. Documentation of normal function and variation in this complement of subtypes, particularly their differentiation ...
Lisa B Boyette, Camila Macedo, Kevin Hadi, Beth D Elinoff, John T Walters, Bala Ramaswami, Geetha Chalasani, Juan M Taboas, Fadi G Lakkis, Diana M Metes   +9 more
doaj   +1 more source

Monocytes presenting a pro-inflammatory profile persist in patients submitted to a long-term pharmacological treatment after acute myocardial infarction

Frontiers in Physiology, 2023
Introduction: Although it is broadly known that monocyte recruitment is involved in atherosclerosis development and that, in accordance with the microenvironment, these cells can be modulated into three well-known subpopulations: Classical (CD14++CD16−),
Daniel Carneiro de Carvalho, Francisco Antonio Helfenstein Fonseca, Maria Cristina de Oliveira Izar, Ana Luíza Pereira Assunção Silveira, Izabela Dorota Tuleta, Jônatas Bussador do Amaral, Lucas Melo Neves, André Luis Lacerda Bachi, Carolina Nunes França   +8 more
doaj   +1 more source

Relationship between the functional activity of in vitro generated monocyte-derived dendritic cells and the presence of CD16 ⁺ cells among peripheral blood monocytes

Медицинская иммунология, 2020
Peripheral blood monocytes are heterogeneous CD14+ cell population, some of which also express CD16 molecule. Differences in phenotype between monocyte subpopulations can affect their functional activity, as well as the ability to further differentiate ...
T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, L. V. Sakhno, A. A. Maximova, А. A. Ostanin, E. R. Chernykh   +6 more
doaj   +1 more source

Towards a refined definition of monocyte subsets

Frontiers in Immunology, 2013
In a nomenclature proposal published in 2010 monocytes were subdivided into classical and nonclassical cells and in addition an intermediate monocyte subset was proposed.
Loems eZiegler-Heitbrock, Thomas PJ Hofer   +1 more
doaj   +1 more source

Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais. [PDF]

J Neuroimmunol, 2015
Ndhlovu LC, D'Antoni ML, Ananworanich J, Byron MM, Chalermchai T, Sithinamsuwan P, Tipsuk S, Ho E, Slike BM, Schuetz A, Zhang G, Agsalda-Garcia M, Shiramizu B, Shikuma CM, Valcour V, SEARCH 011 study group.   +15 more
europepmc   +2 more sources

Relationships between serum HMGB1 concentration and subpopulation composition of circulating monocytes in patients with subclinical atherosclerosis

Медицинская иммунология, 2022
Chronic non-infectious inflammation of low intensity is the most important mechanism of development and progression in atherosclerosis. Under the conditions of persistent non-resolving inflammation observed in the vascular wall and atherosclerotic plaque
V. V. Genkel, I. I. Dolgushin, I. L. Baturina, A. Yu. Savochkina, K. V. Nikushkina, A. A. Minasova, L. R. Pykhova, A. S. Kuznetcova, I. I. Shaposhnik   +8 more
doaj   +1 more source

Epigenetics in non-classical monocytes support their pro-inflammatory gene expression

Immunobiology, 2020
Non-classical human monocytes are characterized by high-level expression of cytokines like TNF, but the mechanisms involved are elusive. We have identified miRNAs and CpG-methylation sites that are unique to non-classical monocytes, defined via CD14 and CD16 expression levels. For down-regulated miRNAs that are linked to up-regulated mRNAs the dominant
Zhang, L., Hofer, T.P., Zawada, A.M., Rotter, B., Krezdorn, N., Nößner, E., Devaux, Y., Heine, G., Ziegler-Heitbrock, L.   +8 more
openaire   +4 more sources

Non-classical and intermediate monocytes in patients following venous thromboembolism: Links with inflammation [PDF]

Advances in Clinical and Experimental Medicine, 2018
Monocyte subsets are involved in atherosclerotic vascular disease and its thromboembolic complications. Moreover, the role of monocytes has been suggested in the pathogenesis of venous thromboembolism (VTE).We hypothesized that pro-inflammatory non-classical and intermediate monocytes are increased in the first months following VTE.We enrolled 70 ...
Wypasek, Ewa, Padjas, Agnieszka, Szymańska, Magdalena, Plens, Krzysztof, Siedlar, Maciej, Undas, Anetta   +5 more
openaire   +3 more sources

MONOCYTE SUBSETS IN RELAPSING REMITTING MULTIPLE SCLEROSIS EGYPTIAN PATIENTS [PDF]

Ain Shams Medical Journal, 2023
Background: Although many types of immune cells are involved in multiple sclerosis (MS) progression, activated monocytes are believed to be one of the first to arrive at the brain and initiate inflammation.
Hala Mohamed, Rasha Saleh, Sara Taha, Shaimaa Mohamed, Nada Kamal   +4 more
doaj   +1 more source

Monocyte subsets display age-dependent alterations at fasting and undergo non-age-dependent changes following consumption of a meal

Immunity & Ageing, 2022
Background Monocytes are a heterogenous population of immune cells whose subsets and functions become substantially dysregulated with advanced age. Although much of our current understanding of the age-related changes in monocytes is derived from fasting
Ryan G. Snodgrass, Xiaowen Jiang, Charles B. Stephensen   +2 more
doaj   +1 more source