6-Sulfo LacNAc (Slan) as a Marker for Non-classical Monocytes [PDF]
Frontiers in Immunology, 2019 Monocytes are subdivided into three subsets, which have different phenotypic and functional characteristics and different roles in inflammation and malignancy.
Thomas P. Hofer +4 more
doaj +9 more sources
Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes. [PDF]
Sci Rep, 2020 Abstract Monocytes are a critical component of the cellular innate immune system, and can be subdivided into classical, intermediate and non-classical subsets on the basis of surface CD14 and CD16 expression. Classical monocytes play the canonical role of phagocytosis, and account for the majority of circulating cells.
Ravenhill BJ +4 more
europepmc +7 more sources
In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets [PDF]
Proteomes, 2018 Monocytes are bone marrow-derived leukocytes that are part of the innate immune system. Monocytes are divided into three subsets: classical, intermediate and non-classical, which can be differentiated by their expression of some surface antigens, mainly ...
Víctor Segura +18 more
doaj +8 more sources
Increased frequency of IL-6-producing non-classical monocytes in neuromyelitis optica spectrum disorder [PDF]
Journal of Neuroinflammation, 2017 Background Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system that preferentially affects the optic nerves, spinal cord, and area postrema. A series of evidence suggested that B cells play a
Byung Soo Kong +6 more
doaj +2 more sources
GM-CSF production by non-classical monocytes controls antagonistic LPS-driven functions in allergic inflammation. [PDF]
Cell Rep, 2021 Kaur K +6 more
europepmc +2 more sources
Anti-β7 integrin treatment impedes the recruitment on non-classical monocytes to the gut and delays macrophage-mediated intestinal wound healing. [PDF]
Clin Transl Med, 2023 Sommer K +14 more
europepmc +2 more sources
Diminished Non-Classical Monocytes in the Blood Associate with Disease Severity in Alcoholic Hepatitis. [PDF]
Clin Exp Gastroenterol, 2021 Alcoholic hepatitis (AH) holds a high mortality, and vast macrophage infiltration of the liver is involved in the progressive liver injury. No efficient medical treatment exists, and macrophages may be a future treatment target. Here, we examine associations between non-classical monocyte subsets and cell surface markers of migration with disease ...
Rasmussen EB +7 more
europepmc +8 more sources
Non-classical monocytes in tissue injury and cancer. [PDF]
Oncotarget, 2017 Bharat A +2 more
europepmc +3 more sources
Non-classical monocytes as mediators of tissue destruction in arthritis. [PDF]
Ann Rheum Dis, 2018 Bone destruction in rheumatoid arthritis is mediated by osteoclasts (OC), which are derived from precursor cells of the myeloid lineage. The role of the two monocyte subsets, classical monocytes (expressing CD115, Ly6C and CCR2) and non-classical monocytes (which are CD115 positive, but low in Ly6C and CCR2), in serving as precursors for OC in ...
Puchner A +22 more
europepmc +5 more sources
Patrolling Mechanics of Non-Classical Monocytes in Vascular Inflammation. [PDF]
Front Cardiovasc Med, 2017 Non-classical monocytes have emerged as the preeminent vascular housekeepers. Continuous intravascular screening is enabled by slow patrolling on the endothelium and allows a rapid response to local perturbations. Intravital imaging has been crucial to elucidate the molecular mechanisms and migratory phenotype of patrolling.
Buscher K +3 more
europepmc +5 more sources