Results 31 to 40 of about 39,020 (125)

Recent advances in the functional explorations of nuclear microRNAs

Frontiers in Immunology, 2023
Approximately 22 nucleotide-long non-coding small RNAs (ncRNAs) play crucial roles in physiological and pathological activities, including microRNAs (miRNAs).
Xiaozhu Hu, Xiaozhu Hu, Guoquan Yin, Guoquan Yin, Yuan Zhang, Yuan Zhang, Liangyu Zhu, Liangyu Zhu, Haoyu Huang, Haoyu Huang, Kun Lv, Kun Lv   +11 more
doaj   +1 more source

Interpretable RNA Foundation Model from Unannotated Data for Highly Accurate RNA Structure and Function Predictions [PDF]

arXiv, 2022
Non-coding RNA structure and function are essential to understanding various biological processes, such as cell signaling, gene expression, and post-transcriptional regulations. These are all among the core problems in the RNA field. With the rapid growth of sequencing technology, we have accumulated a massive amount of unannotated RNA sequences.
arxiv  

B lymphocytes transdifferentiate into immunosuppressive erythroblast-like cells

Frontiers in Immunology, 2023
Recent studies have demonstrated that a particular group of nucleated cells that exhibit erythroid markers (TER119 in mice and CD235a in humans) possess the ability to suppress the immune system and promote tumor growth.
Zhe Yang, Zhe Yang, Zheng Wang, Lei Wu, Lei Wu, Ying Wang, Ying Wang, Zhihui Xu, Ying Liu, Ying Liu, Fangfang Wang, Fangfang Wang, Duonan Yu, Duonan Yu   +13 more
doaj   +1 more source

Alignment-free comparative genomic screen for structured RNAs using coarse-grained secondary structure dot plots

BMC Genomics, 2017
Background Structured non-coding RNAs play many different roles in the cells, but the annotation of these RNAs is lacking even within the human genome.
Yuki Kato, Jan Gorodkin, Jakob Hull Havgaard   +2 more
doaj   +1 more source

The synergistic immunotherapeutic impact of engineered CAR-T cells with PD-1 blockade in lymphomas and solid tumors: a systematic review

Frontiers in Immunology
Currently, therapies such as chimeric antigen receptor-T Cell (CAR-T) and immune checkpoint inhibitors like programmed cell death protein-1 (PD-1) blockers are showing promising results for numerous cancer patients.
Bibhu Prasad Satapathy, Pooja Sheoran, Rohit Yadav, Dewan Chettri, Dhruba Sonowal, Chinmayee Priyadarsini Dash, Prachi Dhaka, Vivek Uttam, Ritu Yadav, Manju Jain, Aklank Jain   +10 more
doaj   +1 more source

Predicting RNA-small molecule binding sites by 3D structure [PDF]

arXiv, 2023
The prediction of RNA-small molecule binding sites is crucial for the discovery of effective drugs. Various computational methods have been developed to address this challenge, using information about the structure and sequence of RNA. In this study, we introduce CplxCavity, a combination of a new algorithm and a machine learning model specifically ...
arxiv  

Antitumor activity of genetically engineered NK-cells in non-hematological solid tumor: a comprehensive review

Frontiers in Immunology
Recent advancements in genetic engineering have made it possible to modify Natural Killer (NK) cells to enhance their ability to fight against various cancers, including solid tumors.
Chinmayee Priyadarsini Dash, Dhruba Sonowal, Prachi Dhaka, Rohit Yadav, Dewan Chettri, Bibhu Prasad Satapathy, Pooja Sheoran, Vivek Uttam, Manju Jain, Aklank Jain   +9 more
doaj   +1 more source

The impact of PrsA over-expression on the Bacillus subtilis transcriptome during fed-batch fermentation of alpha-amylase production

Frontiers in Microbiology, 2022
The production of the alpha-amylase (AMY) enzyme in Bacillus subtilis at a high rate leads to the accumulation of unfolded AMY, which causes secretion stress. The over-expression of the PrsA chaperone aids enzyme folding and reduces stress.
Adrian S. Geissler, Line D. Poulsen, Nadezhda T. Doncheva, Christian Anthon, Stefan E. Seemann, Enrique González-Tortuero, Anne Breüner, Lars J. Jensen, Carsten Hjort, Jeppe Vinther, Jan Gorodkin   +10 more
doaj   +1 more source

Single-photon microscopy to study biomolecular condensates

Nature Communications, 2023
Biomolecular condensates serve as membrane-less compartments within cells, concentrating proteins and nucleic acids to facilitate precise spatial and temporal orchestration of various biological processes.
Eleonora Perego, Sabrina Zappone, Francesco Castagnetti, Davide Mariani, Erika Vitiello, Jakob Rupert, Elsa Zacco, Gian Gaetano Tartaglia, Irene Bozzoni, Eli Slenders, Giuseppe Vicidomini   +10 more
doaj   +1 more source

Bio-Conjugated Quantum Dots for Cancer Research: Detection and Imaging

Frontiers in Oncology, 2021
Ultrasound, computed tomography, magnetic resonance, and gamma scintigraphy-based detection and bio-imaging technologies have achieved outstanding breakthroughs in recent years.
Zhengyan Liang, Zhengyan Liang, Muhammad Babar Khawar, Muhammad Babar Khawar, Muhammad Babar Khawar, Jingyan Liang, Jingyan Liang, Haibo Sun, Haibo Sun   +8 more
doaj   +1 more source