Results 31 to 40 of about 970,725 (346)
Emerging role of non‐coding RNA in health and disease
Metabolic brain disease, 2021 Human diseases have always been a significant turf of concern since the origin of mankind. It is cardinal to know the cause, treatment, and cure for every disease condition.
G. K. Bhatti +6 more
semanticscholar +1 more source
The non-coding RNAs as riboregulators [PDF]
Nucleic Acids Research, 2001 The non-coding RNAs database (http://biobases.ibch.poznan.pl/ncRNA/) contains currently available data on RNAs, which do not have long open reading frames and act as riboregulators. Non-coding RNAs are involved in the specific recognition of cellular nucleic acid targets through complementary base pairing to control cell growth and differentiation ...
Maciej Szymanski +5 more
openaire +3 more sources
Role of Non-Coding RNAs in Colorectal Cancer: Focus on Long Non-Coding RNAs
International Journal of Molecular Sciences, 2022 Colorectal cancer is one of the most common causes of cancer-related deaths worldwide. Despite the advances in the knowledge of pathogenetic molecular mechanisms and the implementation of more effective drug treatments in recent years, the overall survival rate of patients remains unsatisfactory.
Lulli, Matteo +4 more
openaire +3 more sources
Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans
Nature Communications, 2016 Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of ...
L. Holdt +17 more
semanticscholar +1 more source
Cells, 2020 miR-28-5p is downregulated in some tumor tissues in which it has been demonstrated to have tumor suppressor (TS) activity. Here, we demonstrate that miR-28-5p acts as a TS in prostate cancer (PCa) cells affecting cell proliferation/survival, as well as ...
Sofia Fazio +7 more
doaj +1 more source
Expression of long non-coding RNA and mRNA in the hippocampus of mice with type 2 diabetes
Molecular Medicine Reports, 2018 Long non-coding RNAs (lncRNAs) serve key roles in cell growth, development and various diseases associated with the central nervous system. However, differential expression profiles of lncRNAs in type 2 diabetes have not been reported.
L. Ci +7 more
semanticscholar +1 more source
Small non-coding RNA therapeutics for cardiovascular disease
European Heart Journal, 2022 Novel bio-therapeutic agents that harness the properties of small, non-coding nucleic acids hold great promise for clinical applications. These include antisense oligonucleotides that inhibit messenger RNAs, microRNAs (miRNAs), or long non-coding RNAs ...
A. Shah, M. Giacca
semanticscholar +1 more source
Combined VEGFR and MAPK pathway inhibition in angiosarcoma
Scientific Reports, 2021 Angiosarcoma is an aggressive malignancy of endothelial cells that carries a high mortality rate. Cytotoxic chemotherapy can elicit clinical responses, but the duration of response is limited.
Michael J. Wagner +12 more
doaj +1 more source
The functional role of long non-coding RNA in human carcinomas
Molecular Cancer, 2011 Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however
E. Gibb, Carolyn J. Brown, W. Lam
semanticscholar +1 more source
Identification and characterization of novel conserved RNA structures in Drosophila
BMC Genomics, 2018 Background Comparative genomics approaches have facilitated the discovery of many novel non-coding and structured RNAs (ncRNAs). The increasing availability of related genomes now makes it possible to systematically search for compensatory base changes –
Rebecca Kirsch +5 more
doaj +1 more source