Results 91 to 100 of about 385,299 (305)

Long Non-coding RNAs in Bacterial Infections [PDF]

, 2017
Bacterial pathogens have coevolved with their hosts and acquired strategies to circumvent defense mechanisms of host cells. It was shown that bacteria interfere with the expression of mammalian microRNAs to modify immune signaling, autophagy, or the ...
Bruegge, Jennifer zur, Einspanier, Ralf, Sharbati, Soroush   +2 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Application of integrated nested Laplace approximation to identify hot spots of methylation heterogeneity in healthy individuals from the MAMELI cohort

Frontiers in Genetics
DNA methylation is an epigenetic regulator of gene expression and cell identity, which can be shaped by both physiological and pathological factors, including environmental exposure.
Tiago Nardi, Eva Dariol, Rachele Matsagani, Donya Zojaji, Stefano Gustincich, Luca Pandolfini, Elia Biganzoli, Valentina Bollati   +7 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Telomeric DNA damage response mediates neurotoxicity of Aβ42 oligomers in Alzheimer’s disease

The EMBO Journal
Ageing is the major risk factor for Alzheimer’s disease (AD), the most common neurodegenerative disorder. DNA damage is a hallmark of ageing, particularly when occurring at telomeres, genomic regions vulnerable to oxidative damage and often challenging ...
Sara Sepe, Federica Rey, Alexandra Mancheno-Ferris, Alessandra Bigi, Giulia Fani, Devid Damiani, Matteo Cabrini, Eugenia Marinelli, Julio Aguado, Liliana Contu, Alessia di Lillo, Sara Boggio, Sara Tavella, Ilaria Rosso, Stefano Gustincich, Fabrizio Chiti, Fabrizio d’Adda di Fagagna   +16 more
doaj   +1 more source

Small Open Reading Frames, Non-Coding RNAs and Repetitive Elements in Bradyrhizobium japonicum USDA 110 [PDF]

, 2016
Small open reading frames (sORFs) and genes for non-coding RNAs are poorly investigated components of most genomes. Our analysis of 1391 ORFs recently annotated in the soybean symbiont Bradyrhizobium japonicum USDA 110 revealed that 78% of them contain ...
Cuklina, Jelena, Evguenieva-Hackenberg, Elena, Gelfand, Mikhail S., Hahn, Julia, Thalmann, Sebastian, Tsoy, Olga V.   +5 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Structural and functional analysis of four non-coding Y RNAs from Chinese hamster cells: identification, molecular dynamics simulations and DNA replication initiation assays [PDF]

, 2016
Background The genes coding for Y RNAs are evolutionarily conserved in vertebrates. These non-coding RNAs are essential for the initiation of chromosomal DNA replication in vertebrate cells.
Lima, Neto Quirino A, Junior, Francisco FD, Bueno, Paulo SA, Seixas, Flavio AV, Kowalski, Madzia P, Kheir, Eyemen, Krude, Torsten, Fernandez, Maria A   +7 more
core   +9 more sources

Molecular subtypes and the (in vitro) response of glioblastoma to temozolomide

BJC Reports
Background We address the therapeutic relevance of glioblastoma (GBM)’s molecular characterization, focusing on whether a proneural-vs-mesenchymal classification may describe GBM heterogeneity, correlate to stemness and CD44 (a marker often, but ...
Silvia Rancati, Matilde Campolungo, Duarte Gerusa Dalmolin, Pierre Lau, Federica Furia, Alessandro Coppe, Fabio Landuzzi, Manuela Vecchi, Andrea Cavalli, Stefano Gustincich, Nicola Tirelli   +10 more
doaj   +1 more source

Cardiomyopathies: The Role of Non-Coding RNAs

Non-Coding RNA
Cardiomyopathies are the structural and functional disorders of the myocardium. Etiopathogenesis is complex and involves an interplay of genetic, environmental, and lifestyle factors eventually leading to myocardial abnormalities.
Nicole Carabetta, Chiara Siracusa, Isabella Leo, Giuseppe Panuccio, Antonio Strangio, Jolanda Sabatino, Daniele Torella, Salvatore De Rosa   +7 more
doaj   +1 more source