Results 71 to 80 of about 10,779,422 (268)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Molecular Function and Regulation of Non-coding RNAs in Multifactorial Diseases [PDF]

, 2016
Our understanding of the mechanisms underlying the development of multifactorial diseases such as diabetes, autism, Alzheimer's disease, and cancer has been greatly advanced.
Hajjari, Mohammadreza, Mohammadreza Hajjari, Seyed Javad Mowla, Faghihi, Mohammad Ali, Mohammad Ali Faghihi, Mowla, Seyed Javad   +5 more
core   +1 more source

Telomeric DNA damage response mediates neurotoxicity of Aβ42 oligomers in Alzheimer’s disease

The EMBO Journal
Ageing is the major risk factor for Alzheimer’s disease (AD), the most common neurodegenerative disorder. DNA damage is a hallmark of ageing, particularly when occurring at telomeres, genomic regions vulnerable to oxidative damage and often challenging ...
Sara Sepe, Federica Rey, Alexandra Mancheno-Ferris, Alessandra Bigi, Giulia Fani, Devid Damiani, Matteo Cabrini, Eugenia Marinelli, Julio Aguado, Liliana Contu, Alessia di Lillo, Sara Boggio, Sara Tavella, Ilaria Rosso, Stefano Gustincich, Fabrizio Chiti, Fabrizio d’Adda di Fagagna   +16 more
doaj   +1 more source

Cardiomyopathies: The Role of Non-Coding RNAs

Non-Coding RNA
Cardiomyopathies are the structural and functional disorders of the myocardium. Etiopathogenesis is complex and involves an interplay of genetic, environmental, and lifestyle factors eventually leading to myocardial abnormalities.
Nicole Carabetta, Chiara Siracusa, Isabella Leo, Giuseppe Panuccio, Antonio Strangio, Jolanda Sabatino, Daniele Torella, Salvatore De Rosa   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Role of Non-Coding RNAs in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a highly heterogeneous disease, with significantly higher incidence and fatality rates in the elderly. Even with recent decades of research progress in AML, the exact etiology of this deadly disease is still not fully ...
Shailendra S. Maurya, Sarita Maurya, Sumit K. Chaturvedi   +2 more
core   +1 more source

Molecular subtypes and the (in vitro) response of glioblastoma to temozolomide

BJC Reports
Background We address the therapeutic relevance of glioblastoma (GBM)’s molecular characterization, focusing on whether a proneural-vs-mesenchymal classification may describe GBM heterogeneity, correlate to stemness and CD44 (a marker often, but ...
Silvia Rancati, Matilde Campolungo, Gerusa Duarte Dalmolin, Pierre Lau, Federica Furia, Alessandro Coppe, Fabio Landuzzi, Manuela Vecchi, Andrea Cavalli, Stefano Gustincich, Nicola Tirelli   +10 more
doaj   +1 more source

Application of integrated nested Laplace approximation to identify hot spots of methylation heterogeneity in healthy individuals from the MAMELI cohort

Frontiers in Genetics
DNA methylation is an epigenetic regulator of gene expression and cell identity, which can be shaped by both physiological and pathological factors, including environmental exposure.
Tiago Nardi, Eva Dariol, Rachele Matsagani, Donya Zojaji, Stefano Gustincich, Luca Pandolfini, Elia Biganzoli, Valentina Bollati   +7 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

PhyloCSF: a comparative genomics method to distinguish protein-coding and non-coding regions [PDF]

, 2010
As high-throughput transcriptome sequencing provides evidence for novel transcripts in many species, there is a renewed need for accurate methods to classify small genomic regions as protein-coding or non-coding.
Manolis Kellis, Lin, Michael F., Kellis, Manolis, Irwin Jungreis, Michael F. Lin, Jungreis, Irwin   +5 more
core   +1 more source