Results 51 to 60 of about 10,779,422 (268)
Cellular and Molecular Life SciencesIn Alzheimer’s disease (AD), brain levels of Brain-derived neurotrophic factor (BDNF) are reduced. BDNF, a neurotrophin involved in neuronal development and plasticity, has a protective role against the cytotoxic effects of Aβ, a pathological hallmark of
Marta Atzori +8 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The emerging role of long non-coding RNAs in HIV infection
, 2016 The discovery of long non-coding RNAs (lncRNAs) and the elucidation of the mechanisms by which they affect different disease states are providing researchers with a better understanding of a wide array of disease pathways.
Lazar, Daniel C +2 more
core +1 more source
Functional Intricacy and Symmetry of Long Non-Coding RNAs in Parasitic Infections
Frontiers in Cellular and Infection Microbiology, 2021 RNAs are a class of molecules and the majority in eukaryotes are arbitrarily termed non- coding transcripts which are broadly classified as short and long non-coding RNAs.
Joshua Seun Olajide +5 more
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability [PDF]
, 2016 Cells communicate with one another to create microenvironments and share resources. One avenue by which cells communicate is through the action of exosomes.
Burdach, J +14 more
core +1 more source
4D Single-particle tracking with asynchronous read-out single-photon avalanche diode array detector
Nature CommunicationsSingle-particle tracking techniques enable investigation of the complex functions and interactions of individual particles in biological environments. Many such techniques exist, each demonstrating trade-offs between spatiotemporal resolution, spatial ...
Andrea Bucci +8 more
doaj +1 more source
Angiogenesis-related non-coding RNAs and gastrointestinal cancer
Molecular Therapy: Oncolytics, 2021 Gastrointestinal (GI) cancers are among the main reasons for cancer death globally. The deadliest types of GI cancer include colon, stomach, and liver cancers.
Zahra Sadat Razavi +7 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Non-coding RNAs to aid in neurological prognosis after cardiac arrest [Elektronisk resurs]
, 2018 Cardiovascular disease in general, and sudden cardiac death in particular, have an enormous socio-economic burden worldwide. Despite significant efforts to improve cardiopulmonary resuscitation, survival rates remain low.
Erlinge, David, +7 more
core +1 more source