Results 51 to 60 of about 385,299 (305)

New insights into neurodevelopmental disorders by whole genome sequencing of 100 families from Italy

npj Genomic Medicine
Neurodevelopmental disorders (NDDs) have a strong but largely unexplained genetic basis. Moreover, the genetic architecture of these complex disorders in under-represented communities is poorly studied.
Giovanni Spirito, Sara Trova, Gaia Treves, Khudayar Farmanli, Mariacristina Franzese Canonico, Agata Fant, Stefano Marangoni, Federica Furia, Debora Charrance, Nicola Locci, Sara Gottardo, Francesca Groppo, Vittoria Perseghin, Martina Toscano, Erika Bibbò, Serena Donetti Dontin, Cecilia Cargnelutti, Mélody Colliard, Alessandro Rosina, Anna Maria Beoni, Cristina Bérard, Alessandro Coppe, Paolo Serravalle, Fabio Landuzzi, Francesco Musacchia, Antonio Amoroso, Remo Sanges, Andrea Cavalli, Manuela Vecchi, Laure Obino, Stefano Gustincich   +30 more
doaj   +1 more source

Interrogation of RNA-bound proteome with XRNAX illuminates molecular alterations in the mouse brain affected with dysmyelination

Cell Reports
Summary: RNA-protein interactions orchestrate hundreds of pathways in homeostatic and stressed cells. We applied an RNA-protein interactome capture method called protein cross-linked RNA extraction (XRNAX) to shed light on the RNA-bound proteome in ...
Marta Sztachera, Weronika Wendlandt-Stanek, Remigiusz A. Serwa, Luiza Stanaszek, Michał Smuszkiewicz, Dorota Wronka, Monika Piwecka   +6 more
doaj   +1 more source

Non coding RNAs in aortic aneurysmal disease

Frontiers in Genetics, 2015
An aneurysm is a local dilatation of a vessel wall which is >50% its original diameter. Withinthe spectrum of cardiovascular diseases, aortic aneurysms are among the most challenging to treat.
Aparna eDuggirala, Francesca eDelogu, Timothy G Angelini, Tanya eSmith, Massimo eCaputo, Massimo eCaputo, Cha eRajakaruna, Costanza eEmanueli   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors. [PDF]

, 2019
Retinoblastoma is a rare pediatric tumor of the retina, caused by the homozygous loss of the Retinoblastoma 1 (RB1) tumor suppressor gene. Previous microarray studies have identified changes in the expression profiles of coding genes; however, our ...
Bisht, Madhoolika, Campbell, Moray J, Dotts, Kathleen, Elchuri, Sailaja V, Khetan, Vikas, Krishnakumar, Subrmanian, Kumar, Ranjith, Miles, Wayne O, Nagarajha Selvan, Lakshmi Dhevi, Rajasekaran, Swetha, Rishi, Pukhraj, Sahoo, Debashis, Sivaraman, Karthikeyan   +12 more
core   +1 more source

Regulation of virulence in Francisella tularensis by small non-coding RNAs [PDF]

, 2011
Using a cDNA cloning and sequencing approach we have shown that Francisella tularensis expresses homologues of several small RNAs (sRNAs) that are well-conserved among diverse bacteria.
Alain Charbit, Eric Frapy, Guillaume Postic, Iharilalao Dubail, Jonathan Livny, Karin L. Meibom, Marion Dupuis   +6 more
core   +2 more sources

Long non‐coding RNA modifies chromatin [PDF]

BioEssays, 2011
AbstractCommon themes are emerging in the molecular mechanisms of long non‐coding RNA‐mediated gene repression. Long non‐coding RNAs (lncRNAs) participate in targeted gene silencing through chromatin remodelling, nuclear reorganisation, formation of a silencing domain and precise control over the entry of genes into silent compartments.
Alka Saxena, Piero Carninci??
openaire   +2 more sources

Autophagy-Related ncRNAs in Pancreatic Cancer

Pharmaceuticals, 2022
Pancreatic cancer (PC) is a malignancy accounting for only 3% of total cancers, but with a low 5-year relative survival rate. Approximately 80% of PC patients are diagnosed at a late stage when the disease has already spread from the primary site ...
Simone Donati, Cinzia Aurilia, Gaia Palmini, Irene Falsetti, Teresa Iantomasi, Maria Luisa Brandi   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Non-Coding RNAs in Endometrial Physiopathology [PDF]

International Journal of Molecular Sciences, 2018
The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene regulation. They have been classified, according to their
La Ferlita, Alessandro, Battaglia, Rosalia, Andronico, Francesca, Caruso, Salvatore, Cianci, Antonio, Purrello, Michele, Di Pietro, Cinzia   +6 more
openaire   +2 more sources