Results 31 to 40 of about 10,779,422 (268)

Differential Allelic Expression among Long Non-Coding RNAs

, 2021
Long non-coding RNAs (lncRNA) comprise a diverse group of non-protein-coding RNAs >200 bp in length that are involved in various normal cellular processes and disease states, and can affect coding gene expression through mechanisms in cis or in trans ...
Paul T. Spellman, Michael B. Heskett, Mathew J. Thayer   +2 more
core   +1 more source

Functional and evolutionary characterization of flowering-related long non-coding RNAs [PDF]

, 2021
Genomweite Bemühungen haben eine große Anzahl langer nichtkodierender RNAs (lncRNAs) identifiziert, obwohl ihre möglichen Funktionen weitgehend rätselhaft bleiben.
Chen, Li
core   +1 more source

Construction and validation of prognostic nomogram for metaplastic breast cancer

Biomolecules & Biomedicine, 2022
In this study we aimed to develop nomogram models for predicting the overall survival (OS) and cancer-specific survival (CSS) of patients with metaplastic breast cancer (MBC). Data of patients diagnosed with MBC from 1973 to 2015 were collected from the
Yongfeng Li, Daobao Chen, Haojun Xuan, Mihnea P. Dragomir, George A. Calin, Xuli Meng, Meng Chen, Hongchuan Jin   +7 more
doaj   +1 more source

New insights into neurodevelopmental disorders by whole genome sequencing of 100 families from Italy

npj Genomic Medicine
Neurodevelopmental disorders (NDDs) have a strong but largely unexplained genetic basis. Moreover, the genetic architecture of these complex disorders in under-represented communities is poorly studied.
Giovanni Spirito, Sara Trova, Gaia Treves, Khudayar Farmanli, Mariacristina Franzese Canonico, Agata Fant, Stefano Marangoni, Federica Furia, Debora Charrance, Nicola Locci, Sara Gottardo, Francesca Groppo, Vittoria Perseghin, Martina Toscano, Erika Bibbò, Serena Donetti Dontin, Cecilia Cargnelutti, Mélody Colliard, Alessandro Rosina, Anna Maria Beoni, Cristina Bérard, Alessandro Coppe, Paolo Serravalle, Fabio Landuzzi, Francesco Musacchia, Antonio Amoroso, Remo Sanges, Andrea Cavalli, Manuela Vecchi, Laure Obino, Stefano Gustincich   +30 more
doaj   +1 more source

Interrogation of RNA-bound proteome with XRNAX illuminates molecular alterations in the mouse brain affected with dysmyelination

Cell Reports
Summary: RNA-protein interactions orchestrate hundreds of pathways in homeostatic and stressed cells. We applied an RNA-protein interactome capture method called protein cross-linked RNA extraction (XRNAX) to shed light on the RNA-bound proteome in ...
Marta Sztachera, Weronika Wendlandt-Stanek, Remigiusz A. Serwa, Luiza Stanaszek, Michał Smuszkiewicz, Dorota Wronka, Monika Piwecka   +6 more
doaj   +1 more source

Epigenetic Regulation by Non-Coding RNAs in the Avian Immune System

Life, 2020
The identified non-coding RNAs (ncRNAs) include circular RNAs, long non-coding RNAs, microRNAs, ribosomal RNAs, small interfering RNAs, small nuclear RNAs, piwi-interacting RNAs, and transfer RNAs, etc.
Xiaolan Chen, Bahareldin Ali Abdalla, Zhenhui Li, Qinghua Nie   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Non-Coding RNAs: Strategy for Viruses’ Offensive

, 2020
The awareness of viruses as a constant threat for human public health is a matter of fact and in this resides the need of understanding the mechanisms they use to trick the host. Viral non-coding RNAs are gaining much value and interest for the potential
Alessia Gallo, Matteo Bulati, Nicola Amodio, Pier Giulio Conaldi, Vitale Miceli   +4 more
core   +1 more source

Roles of non-coding RNAs in ciliate genome architecture. [PDF]

, 2020
Ciliates are an interesting model system for investigating diverse functions of non-coding RNAs, especially in genome defence pathways. During sexual development, the ciliate somatic genome undergoes massive rearrangement and reduction through removal of
Nowacki, Mariusz, Allen, Sarah E.
core   +2 more sources