Rare splice variants in long non-coding RNAs
, 2022 Art. 23, 8 S.Long non-coding RNAs (lncRNAs) form a substantial component of the transcriptome and are involved in a wide variety of regulatory mechanisms.
Stadler, Peter F. +2 more
core +2 more sources
Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy [PDF]
, 2021 Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with a 5-year survival rate less than 8%, which has remained unchanged over the last 50 years.
Uysal Onganer, P. +4 more
core +1 more source
Post-Transcriptional Regulation through Long Non-Coding RNAs (lncRNAs)
, 2021 The discovery of thousands of non-coding RNAs (ncRNAs) pervasively transcribed from the eukaryotic genome has revolutionized the “central dogma” of biology and shifted the attention on the role of RNAs as regulatory molecules, more than simply ...
Giuseppina Pisignano, Michael Ladomery
core +1 more source
Noncoder : a web interface for exon array-based detection of long non-coding RNAs [PDF]
, 2012 Due to recent technical developments, a high number of long non-coding RNAs (lncRNAs) have been discovered in mammals. Although it has been shown that lncRNAs are regulated differently among tissues and disease statuses, functions of these transcripts ...
Braun, Thomas +3 more
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Novel long non-coding RNAs of relevance for ulcerative colitis pathogenesis [PDF]
, 2022 Background and aims: The study aimed to identify yet unknown and uncharacterized long non-coding RNAs (lncRNAs) in treatment-naïve ulcerative colitis (UC), and to define their possible roles in UC pathogenesis.
Paulssen, Ruth H +2 more
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The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis
Molecular Therapy: Nucleic Acids, 2022 Doxorubicin is a chemotherapeutic medication commonly used to treat many types of cancers, but it has side effects including vomiting, rash, hair loss, and bone marrow suppression.
Jindong Xu +7 more
doaj +1 more source
Computational analysis of next generation sequencing data : from transcription start sites in bacteria to human non-coding RNAS [PDF]
, 2014 The advent of next generation sequencing (NGS) technologies has revolutionized the field of molecular biology by providing a wealth of sequence data. “Transcriptomics”, which aims to identify and annotate the complete set of RNA molecules transcribed ...
Jorjani, Hadi
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Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer
Molecular Therapy: Nucleic Acids, 2022 Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. TNBC progression is sustained by recruitment of a strong tumor microenvironment (TME) mainly composed of cancer-associated fibroblasts (CAFs) able to endorse tumor ...
Iolanda Scognamiglio +15 more
doaj +1 more source
An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]
, 2013 Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Darren M. Gowers (485354) +29 more
core +2 more sources