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The development of non-coding RNA ontology [PDF]
, 2016 Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data ...
Blake, Judith +15 more
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Non-Coding RNAs and Cancer [PDF]
International Journal of Molecular Sciences, 2013 The discovery of the biological relevance of non-coding RNA (ncRNAs) molecules represents one of the most significant advances in contemporary molecular biology. Expression profiling of human tumors, based on the expression of miRNAs and other short or long ncRNAs, has identified signatures associated with diagnosis, staging, progression, prognosis ...
Calore, Federica +2 more
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miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities
Cells, 2023 MicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently associated with the onset and progression of human cancers. miR-142, an ultra-conserved miRNA with both active -3p and -5p mature strands and wide-ranging physiological ...
Wilson Huang +3 more
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Non-Coding RNAs in Glioma [PDF]
Cancers, 2018 Glioma is the most aggressive brain tumor of the central nervous system. The ability of glioma cells to migrate, rapidly diffuse and invade normal adjacent tissue, their sustained proliferation, and heterogeneity contribute to an overall survival of approximately 15 months for most patients with high grade glioma.
Ryte Rynkeviciene +8 more
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The Role of LncRNAs in Translation
Non-Coding RNA, 2021 Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins and regulate gene expression at the transcriptional, post-transcriptional ...
Didem Karakas, Bulent Ozpolat
doaj +1 more source
Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease [PDF]
, 2014 It has been recognized for decades that proteins, which are encoded by our genome and produced via transcription and translation steps, are building blocks that play vital roles in almost all biological processes.
Kataoka, Masaharu, Wang, Da-Zhi
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RNA localization is a key determinant of neurite-enriched proteome
Nature Communications, 2017 Subcellular localization of RNAs and proteins is important for polarized cells such as neurons. Here the authors differentiate mouse embryonic stem cells into neurons, and analyze the local transcriptome, proteome, and translated transcriptome in their ...
Alessandra Zappulo +19 more
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Construction and validation of prognostic nomogram for metaplastic breast cancer
Biomolecules & Biomedicine, 2022 In this study we aimed to develop nomogram models for predicting the overall survival (OS) and cancer-specific survival (CSS) of patients with metaplastic breast cancer (MBC). Data of patients diagnosed with MBC from 1973 to 2015 were collected from the
Yongfeng Li +7 more
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Non-coding RNAs in Transcriptional Regulation [PDF]
, 2015 Transcriptional gene silencing guided by small RNAs is a process conserved from protozoa to mammals. Small RNAs loaded into Argonaute family proteins direct repressive histone modifications or DNA cytosine methylation to homologous regions of the genome.
Aravin, Alexei A., Chen, Yung-Chia Ariel
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Epigenetic Regulation by Non-Coding RNAs in the Avian Immune System
Life, 2020 The identified non-coding RNAs (ncRNAs) include circular RNAs, long non-coding RNAs, microRNAs, ribosomal RNAs, small interfering RNAs, small nuclear RNAs, piwi-interacting RNAs, and transfer RNAs, etc.
Xiaolan Chen +3 more
doaj +1 more source