Results 71 to 80 of about 16,629,550 (291)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Antioxidant indices, essential and non-essential amino acids of Phyllanthus niruri leaves extracts

Results in Chemistry
Phyllanthus niruri, a plant commonly utilized in traditional medicine, is known for its healing properties, including its antioxidant capacity and nutritional benefits.
Patience Onakurhefe, Ovovwe Diakparomre, Tracy Ogochukwu Njideaka, Joel Okpoghono   +3 more
doaj   +1 more source

Effects of Dietary L-Glutamine or L-Glutamine Plus L-Glutamic Acid Supplementation Programs on the Performance and Breast Meat Yield Uniformity of 42-d-Old Broilers

Brazilian Journal of Poultry Science, 2015
This study aimed at evaluating four dietary L-Glutamine (L-Gln) or L-Gln plus L-Glutamate (L-Glu) supplementation programs on the performance, breast yield, and uniformity of broilers. A total of 2,112 one-d-old male Cobb 500(r) broilers were distributed
V Ribeiro Jr, LFT Albino, HS Rostagno, MI Hannas, CLN Ribeiro, RA Vieira, WAG de Araújo, GBS Pessoa, RKG Messias, DL da Silva   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Non-targeted metabolomics data from bovine mammary epithelial cells stimulated by ten different essential amino acids

Non-targeted metabolomics data from bovine mammary epithelial cells stimulated by ten different essential amino acids.
Lianbin Xu (17985268), Xiuli Li (133764), Dengpan Bu (369549)   +2 more
core   +1 more source

Enhancing essential amino acid bioavailability of soy protein through Streptococcus thermophilus ST4 supplementation

Frontiers in Microbiology
BackgroundSoy protein is a popular plant-based protein source, but is nutritionally limited by its incomplete essential amino acid profile and lower bioavailability relative to animal proteins.
David Agus Setiawan Wibisono, Chiou-Yeong Saw, Bo-Long Jian, Der-Kai Lau, Der-Kai Lau, Wei-Jen Chen, Hui-Fang Chu, Cheng-Yen Liu, Chi-Fai Chau   +8 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

CHARACTERIZATION OF THE EFFECT OF MODULATED DRY HEAT PROCESSING CONDITIONS ON ESSENTIAL AND NON ESSENTIAL AMINO ACID PROFILE OF UNSEASONED BREADFRUIT (V. DECNE) SNACK SEEDS

Food and Environment Safety, 2018
The objective of this study was to determine the functional relationship between Roasting temperature (RT), Roasting time (RM) and Feed quantity (FQ) and the yield of all essential and non-essential amino-acids obtainable through modulated roasting of ...
Azubuike C UMEZURUIKE, Joel NDIFE, Chinwe NWACHUKWU   +2 more
doaj  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source