Results 11 to 20 of about 341,882 (288)
KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair. [PDF]
PLoS ONE, 2015 Homologous recombination and non-homologous end joining are two major DNA double-strand-break repair pathways. While HR-mediated repair requires a homologous sequence as the guiding template to restore the damage site precisely, NHEJ-mediated repair ...
Yi-Hui Lin +5 more
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Non-homologous DNA end joining.
Acta Biochimica Polonica, 2003 DNA double-strand breaks (DSBs) are a serious threat for the cell and when not repaired or misrepaired can result in mutations or chromosome rearrangements and eventually in cell death. Therefore, cells have evolved a number of pathways to deal with DSB including homologous recombination (HR), single-strand annealing (SSA) and non-homologous end ...
Elzbieta, Pastwa, Janusz, Błasiak
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Non-homologous end joining often uses microhomology: Implications for alternative end joining [PDF]
DNA Repair, 2014 Artemis and PALF (also called APLF) appear to be among the primary nucleases involved in non-homologous end joining (NHEJ) and responsible for most nucleolytic end processing in NHEJ. About 60% of NHEJ events show an alignment of the DNA ends that use 1 or 2bp of microhomology (MH) between the two DNA termini. Thus, MH is a common feature of NHEJ.
Pannunzio, Nicholas +3 more
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Modeling damage complexity-dependent non-homologous end-joining repair pathway.
PLoS ONE, 2014 Non-homologous end joining (NHEJ) is the dominant DNA double strand break (DSB) repair pathway and involves several repair proteins such as Ku, DNA-PKcs, and XRCC4.
Yongfeng Li +3 more
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Synthetic and Systems Biotechnology, 2019 DNA double-strand breaks (DSBs) are one of the most lethal forms of DNA damage that is not efficiently repaired in prokaryotes. Certain microorganisms can handle chromosomal DSBs using the error-prone non-homologous end joining (NHEJ) system and ...
Tianyuan Su +6 more
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PHF6 promotes non‐homologous end joining and G2 checkpoint recovery
EMBO reports, 2019 Abstract The cellular response to DNA breaks is influenced by chromatin compaction. To identify chromatin regulators involved in the DNA damage response, we screened for genes that affect recovery following DNA
Daniël O Warmerdam +9 more
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Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model [PDF]
Genetics and Molecular Biology, 2019 The poly (adenosine diphosphate (ADP)-ribosyl) polymerase inhibitors (PARPi) selectively kill cancer cells with BRCA1 or BRCA2 (BRCA)-mutations. It has been proposed that cell death induction after PARPi depends on unrepaired double strand breaks (DSBs ...
Natalia Soledad Paviolo +6 more
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Frontiers in Plant Science, 2021 Ribosomal RNA genes (rDNAs) are located in large domains of hundreds of rDNA units organized in a head-to-tail manner. The proper and stable inheritance of rDNA clusters is of paramount importance for survival.
Jason Sims +5 more
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Modeling non-homologous end joining [PDF]
Journal of Theoretical Biology, 2011 Non-homologous end joining (NHEJ) is an important DNA repair pathway for DNA double-strand breaks. Several proteins, including Ku, DNA-PKcs, Artemis, XRCC4/Ligase IV and XLF, are involved in the NHEJ for the DNA damage detection, DNA free end processing and ligation. The classical model of NHEJ is a sequential model in which DNA-PKcs is first recruited
Yongfeng, Li, Francis A, Cucinotta
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The endless tale of non-homologous end-joining [PDF]
Cell Research, 2008 DNA double-strand breaks (DSBs) are introduced in cells by ionizing radiation and reactive oxygen species. In addition, they are commonly generated during V(D)J recombination, an essential aspect of the developing immune system. Failure to effectively repair these DSBs can result in chromosome breakage, cell death, onset of cancer, and defects in the ...
Eric, Weterings, David J, Chen
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