Results 31 to 40 of about 341,882 (288)

APLF and long non-coding RNA NIHCOLE promote stable DNA synapsis in non-homologous end joining [PDF]

, 2023
The synapsis of DNA ends is a critical step for the repair of double-strand breaks by non-homologous end joining (NHEJ). This is performed by a multicomponent protein complex assembled around Ku70-Ku80 heterodimers and regulated by accessory factors ...
Unfried, Juan Pablo, Llorca, Oscar, Mikel Marin-Baquero, Juan Pablo Unfried, Arribas-Bosacoma, Raquel; id_orcid, Llorca Blanco, Oscar Antonio, Angel Rivera-Calzada, Laura Prats-Mari, Aicart-Ramos, Clara, Puri Fortes, De Bragança, Sara, Oscar Llorca, Rivera-Calzada, Angel, Clara Aicart-Ramos, Fernando Moreno-Herrero, Fortes, Puri, Arribas-Bosacoma, Raquel, Prats-Mari, Laura, Raquel Arribas-Bosacoma, Marin-Baquero, Mikel, Moreno-Herrero, Fernando, Sara De Bragança   +21 more
core   +1 more source

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting

Acta Neuropathologica Communications, 2023
As the progression of low-grade diffuse astrocytomas into grade 4 tumors significantly impacts patient prognosis, a better understanding of this process is of paramount importance for improved patient care. In this project, we analyzed matched IDH-mutant
Kirsi J. Rautajoki, Serafiina Jaatinen, Anja Hartewig, Aliisa M. Tiihonen, Matti Annala, Iida Salonen, Masi Valkonen, Vili Simola, Elisa M. Vuorinen, Anni Kivinen, Minna J. Rauhala, Riikka Nurminen, Kendra K. Maass, Sirpa-Liisa Lahtela, Arja Jukkola, Olli Yli-Harja, Pauli Helén, Kristian W. Pajtler, Pekka Ruusuvuori, Joonas Haapasalo, Wei Zhang, Hannu Haapasalo, Matti Nykter   +22 more
doaj   +1 more source

The spatial organization of non-homologous end joining: From bridging to end joining

DNA Repair, 2014
Non-homologous end joining (NHEJ) repairs DNA double-strand breaks generated by DNA damage and also those occurring in V(D)J recombination in immunoglobulin and T cell receptor production in the immune system. In NHEJ DNA-PKcs assembles with Ku heterodimer on the DNA ends at double-strand breaks, in order to bring the broken ends together and to ...
Ochi, Takashi, Wu, Qian, Blundell, Tom L
openaire   +2 more sources

Homologous recombination and DNA-end joining reactions in zygotes and early embryos of zebrafish (Danio rerio) and Drosophila melanogaster. [PDF]

, 1998
A linear DNA with partial sequence redundancy can be recircularized in cells by either nonhomologous end joining (NEJ) or by homologous recombination (HR).
Xue, Lei, Georgiev, Oleg, Bruggmann, Rémy, Hagmann, M, Georgiev, O, Schaffner, W, Rungger, Duri, Rungger, D, Gerster, Thomas, Spaniol, Philipp, Schaffner, Walter, Lei, Xue, Gerster, T, Spaniol, P, Hagmann, Michael   +14 more
core   +1 more source

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining.

, 2015
Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non ...
Spanswick, VJ, Maciej T. Luczynski, Rieger, Simone, Luczynski, Maciej T., Cook, Rebecca, Cook, R, Hartley, JA, Paul H. Huang, Victoria J. Spanswick, Huang, Paul H., Hartley, John A., John A. Hartley, Luczynski, MT, Rieger, S, Mittnacht, Sibylle, Mittnacht, S, Spanswick, Victoria J., Moquet, J, Huang, PH, Kai Rothkamm, Zoumpoulidou, Georgia, Jayne Moquet, Zoumpoulidou, G, Georgia Zoumpoulidou, Simone Rieger, Sibylle Mittnacht, Rothkamm, K, Rebecca Cook, Moquet, Jayne, Rothkamm, Kai   +29 more
core   +1 more source

Inhibition of KU70 and KU80 by CRISPR interference, not NgAgo interference, increases the efficiency of homologous recombination in pig fetal fibroblasts

Journal of Integrative Agriculture, 2019
Non-homologous end-joining (NHEJ) is a predominant pathway for the repair of DNA double-strand breaks (DSB). It inhibits the efficiency of homologous recombination (HR) by competing for DSB targets.
Guo-ling LI, Rong QUAN, Hao-qiang WANG, Xiao-fang RUAN, Jian-xin MO, Cui-li ZHONG, Hua-qiang YANG, Zi-cong LI, Ting GU, De-wu LIU, Zhen-fang WU, Geng-yuan CAI, Xian-wei ZHANG   +12 more
doaj   +1 more source

non-homologous end-joining-png

, 2014
unigenes associated with non-homologous end ...
Karen Fugate (480954)
core   +1 more source

non-homologous end-joining-html

, 2014
unigenes involved in non-homologous end ...
Karen Fugate (480954)
core   +1 more source

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells

, 2005
Class switch recombination (CSR) is a region-specific, transcriptionally regulated, nonhomologous recombinational process that is initiated by activation-induced cytidine deaminase (AID).
Lennart Hammarström, Hammarström, L,, Lahdesmaki, A, Aleksi Lähdesmäki, Wei Zhou, Andrew R. Gennery, Jones, AM, Michael R. Ehrenstein, Pan-Hammarstrom, Q, Hammarstrom, L, Zhou, W, Gennery, AR, Ehrenstein, MR, Anne-Marie Jones, Richard A. Gatti, Gatti, RA, Qiang Pan-Hammarström   +16 more
core   +1 more source

Lif1 SUMOylation and its role in non-homologous end-joining [PDF]

Nucleic Acids Research, 2013
Non-homologous end-joining (NHEJ) repairs DNA double-strand breaks by tethering and ligating the two DNA ends. The mechanisms regulating NHEJ efficiency and interplay between its components are not fully understood. Here, we identify and characterize the SUMOylation of budding yeast Lif1 protein, which is required for the ligation step in NHEJ. We show
Vigasova, Dana, Sarangi, Prabha, Kolesar, Peter, Vlasáková, Danuša, Slezakova, Zuzana, Altmannova, Veronika, Nikulenkov, Fedor, Anrather, Dorothea, Gith, Rainer, Zhao, Xiaolan, Chovanec, Miroslav, Krejci, Lumir   +11 more
openaire   +2 more sources