Results 261 to 270 of about 341,882 (288)
Some of the next articles are maybe not open access.
Non‐homologous DNA end joining in the mature rat brain
Journal of Neurochemistry, 2002AbstractRecent evidence suggests that DNA double strand breaks (DSBs) are introduced in neurons during the course of normal development, and that repair of such DSBs is essential for neuronal survival. Here we describe a non‐homologous DNA end joining (NHEJ) system in the adult rat brain that may be used to repair DNA DSBs.
Keqin, Ren, Sandra, Peña de Ortiz
openaire +2 more sources
The role of the non‐homologous end‐joining pathway in lymphocyte development
Immunological Reviews, 2004Summary: One of the most toxic insults a cell can incur is a disruption of its linear DNA in the form of a double‐strand break (DSB). Left unrepaired, or repaired improperly, these lesions can result in cell death or neoplastic transformation. Despite these dangers, lymphoid cells purposely introduce DSBs into their genome to maximize the diversity ...
Sean, Rooney +2 more
openaire +2 more sources
Mechanism and regulation of human non-homologous DNA end-joining
Nature Reviews Molecular Cell Biology, 2003Non-homologous DNA end-joining (NHEJ)--the main pathway for repairing double-stranded DNA breaks--functions throughout the cell cycle to repair such lesions. Defects in NHEJ result in marked sensitivity to ionizing radiation and ablation of lymphocytes, which rely on NHEJ to complete the rearrangement of antigen-receptor genes.
Michael R, Lieber +3 more
openaire +2 more sources
The clinical impact of deficiency in DNA non-homologous end-joining
DNA Repair, 2014DNA non-homologous end-joining (NHEJ) is the major DNA double strand break (DSB) repair pathway in mammalian cells. Defects in NHEJ proteins confer marked radiosensitivity in cell lines and mice models, since radiation potently induces DSBs. The process of V(D)J recombination functions during the development of the immune response, and involves the ...
Woodbine L, Gennery AR, Jeggo PA
openaire +3 more sources
Biochemistry (Moscow)
Double-strand DNA break (DSB) repair mechanisms vary in their ability to prevent errors during end joining. The joining of DSBs on different chromosomes can result in translocations, potentially leading to tumorigenesis. This review examines the main mechanisms of DSB repair and factors influencing their selection, as well as contribution of these ...
Nikolai A, Lomov +3 more
openaire +2 more sources
Double-strand DNA break (DSB) repair mechanisms vary in their ability to prevent errors during end joining. The joining of DSBs on different chromosomes can result in translocations, potentially leading to tumorigenesis. This review examines the main mechanisms of DSB repair and factors influencing their selection, as well as contribution of these ...
Nikolai A, Lomov +3 more
openaire +2 more sources
Non-homologous end-joining: bacteria join the chromosome breakdance
Trends in Biochemical Sciences, 2003The repair of DNA double-strand breaks by non-homologous end-joining (NHEJ) has long been thought to be restricted to eukaryotes. However, recent papers document the existence of operons encoding functional NHEJ complexes in some bacteria. These findings provide new evolutionary insights into the core biochemistry of this repair pathway, and suggest ...
Thomas E, Wilson +2 more
openaire +2 more sources
Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining
Nature Reviews Molecular Cell Biology, 2021Dale A Ramsden +2 more
exaly
The molecular basis and disease relevance of non-homologous DNA end joining
Nature Reviews Molecular Cell Biology, 2020Bailin Zhao +2 more
exaly