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Correction for Wang et al., The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining. [PDF]

Proc Natl Acad Sci U S A
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The role of BRCA1 in non-homologous end-joining

Cancer Letters, 2006
From the genotypic viewpoint, single nucleotide polymorphisms in the genes of the non-homologous end-joining (NHEJ) pathway, which is important in the repair of DNA double-strand breaks, have been shown to be associated with increased breast cancer risk. However, more phenotypic evidence is needed to strengthen the link between defective NHEJ genes and
Da-Tian Bau, Chen-Yang Shen
exaly   +3 more sources

The mechanism of non-homologous end-joining: a synopsis of synapsis

DNA Repair, 2004
Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ) is required for resistance to genotoxic agents, such as ionizing radiation, but also for proper development of the vertebrate immune system. Much progress has been made in identifying the factors that are involved in this repair pathway.
Eric Weterings, Dik C Van Gent
exaly   +4 more sources

Coevolution of non-homologous end joining efficiency and encephalization

Journal of Evolutionary Biology
Abstract Double-strand breaks (DSB), the most difficult to repair DNA damage, are mainly repaired by non-homologous end-joining (NHEJ) or homologous recombination (HR). Previous studies seem to indicate that primates, and particularly humans, have a better NHEJ system.
Ion Udroiu, Antonella Sgura
openaire   +4 more sources

NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae

Nature, 2001
Broken DNA ends are rejoined by non-homologous end-joining (NHEJ) pathways requiring the Ku proteins (Ku70, Ku80), DNA ligase IV and its associated protein Lif1/Xrcc4 (ref. 1). In mammalian meiotic cells, Ku protein levels are much lower than in somatic cells, apparently reducing the capacity of meiotic cells to carry out NHEJ and thereby promoting ...
M, Valencia, M, Bentele, M B, Vaze, G, Herrmann, E, Kraus, S E, Lee, P, Schär, J E, Haber   +7 more
openaire   +3 more sources

Dynamic assemblies and coordinated reactions of non-homologous end joining

Nature
Non-homologous end joining (NHEJ) is the main repair pathway of double-strand DNA breaks in higher eukaryotes1,2. Here we report reconstitution of the final steps of NHEJ and structures of DNA polymerase μ and ligase IV (LIG4) engaged in gap filling and end joining.
Jeremy M Stark, Martin Gellert, Wei Yang   +2 more
exaly   +3 more sources

One ring to bring them all—The role of Ku in mammalian non-homologous end joining

DNA Repair, 2014
The repair of DNA double strand breaks is essential for cell survival and several conserved pathways have evolved to ensure their rapid and efficient repair. The non-homologous end joining pathway is initiated when Ku binds to the DNA break site.
Keith W Caldecott
exaly   +2 more sources

Non-homologous DNA end joining and alternative pathways to double-strand break repair [PDF]

Nature Reviews Molecular Cell Biology, 2017
DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that occur throughout the cell cycle are repaired predominantly by the non-homologous
Nicholas R Pannunzio, Noritaka Adachi, Michael R Lieber   +2 more
exaly   +2 more sources

Non-Homologous DNA End Joining in Anticancer Therapy

Current Cancer Drug Targets, 2007
Non-homologous DNA end joining (NHEJ) is the major pathway for the repair of double-strand breaks (DSBs) in human cells. Proteins involved in NHEJ pathway can become molecular targets in the treatment of cancer. Inhibition of this pathway leads to radio- and chemosensitization of cancer cells.
Elzbieta, Pastwa, Mariusz, Malinowski
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Bacterial DNA repair by non-homologous end joining

Nature Reviews Microbiology, 2007
The capacity to rectify DNA double-strand breaks (DSBs) is crucial for the survival of all species. DSBs can be repaired either by homologous recombination (HR) or non-homologous end joining (NHEJ). The long-standing notion that bacteria rely solely on HR for DSB repair has been overturned by evidence that mycobacteria and other genera have an NHEJ ...
Stewart, Shuman, Michael S, Glickman
openaire   +2 more sources