Results 231 to 240 of about 341,882 (288)

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin

Simões-Sousa S, Amin N, Lane KA, Harrod A, Pedersen M, Pardo M, Rasetti-Escargueil C, Kozik Z, Begg KAG, Ribeiro A, Banerjee S, Stucki M, Harrington KJ, Choudhary JS, Downs JA.   +14 more
europepmc   +1 more source

BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer. [PDF]

J Exp Clin Cancer Res
Sriramulu S, Thoidingjam S, Chen WM, Hassan O, Siddiqui F, Brown SL, Movsas B, Green MD, Davis AJ, Speers C, Walker E, Nyati S.   +11 more
europepmc   +1 more source

Biomaterial‐Integrated Electroporation for Therapeutic Delivery: From Gene Editing to Tumor Ablation and Immune Modulation

Small, EarlyView.
Biomaterial‐integrated electroporation establishes a programmable therapeutic interface that coordinates electric‐field modulation, transient or irreversible membrane permeabilization, cargo stabilization, and immune remodeling. This Review highlights how nanocarriers, hydrogels, and bioelectronic interfaces expand electroporation from conventional ...
Binbin Ji, Zhuozhuo Wu, Yuyue Jiang, Xiaoyu Liu, Jingfeng Li, Fengkuo Xu, Chaojie Li, Qungang Shan, Ziyin Wang, Junhao Wang, Wei Huang, Yaping Zhuang, Wenguo Cui, Zhongmin Wang   +13 more
wiley   +1 more source

Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining. [PDF]

Nat Commun
Stinson BM, Carney SM, Walter JC, Loparo JJ.   +3 more
europepmc   +1 more source

Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang, Teng‐Fei Li, Tian‐Yu Wang, Huan‐Hai Liu   +3 more
wiley   +1 more source

Genome-scale transcriptional activation by non-homologous end joining-mediated integration in Yarrowia lipolytica. [PDF]

Biotechnol Biofuels Bioprod
Liu X, Deng J, Zhang J, Cui Z, Qi Q, Hou J.   +5 more
europepmc   +1 more source

One Yeast, Sixteen Synthetic Chromosomes, Infinite Possibilities

Yeast, EarlyView.
ABSTRACT The evolution of the yeast, Saccharomyces cerevisiae, from a genetically tractable model organism to a chassis for genome‐scale engineering represents one of the most influential trajectories in eukaryotic biology. The Synthetic Yeast Genome Project (Sc2.0) embodies the current height of this trajectory, having now delivered functional ...
Edward Archer, Roy S. K. Walker, Paige E. Erpf, Ian T. Paulsen, Isak S. Pretorius   +4 more
wiley   +1 more source

Modelling Heterogeneous Anomalous Dynamics of Radiation-Induced Double-Strand Breaks in DNA during Non-Homologous End-Joining Pathway. [PDF]

Entropy (Basel)
Korabel N, Warmenhoven JW, Henthorn NT, Ingram S, Fedotov S, Heaven CJ, Kirkby KJ, Taylor MJ, Merchant MJ.   +8 more
europepmc   +1 more source

Comparative Analysis of Stress Adaptation in the Yeast Microbiome of Cactus

Yeast, EarlyView.
Yeasts and related fungi isolated from cacti or nearby non‐cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host. ABSTRACT Together with other fungi, yeasts make up a significant component of the plant microbiome. As the planet warms, cacti expand their range.
Alya N. Hussain, Kevin T. Fotso, Michael A. McMurray   +2 more
wiley   +1 more source