Results 41 to 50 of about 648,128 (302)

Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson’s Disease

Frontiers in Aging Neuroscience, 2018
Though Parkinson’s disease (PD) clinical picture is generally dominated by motor impairment, non-motor symptoms, such as cognitive decline and gastrointestinal dysfunctions, may develop before motor symptoms and have major effects on quality of life. L-3,
Paula Perez-Pardo, Laus M. Broersen, Laus M. Broersen, Tessa Kliest, Nick van Wijk, Amos Attali, Johan Garssen, Johan Garssen, Aletta D. Kraneveld   +8 more
doaj   +1 more source

Functional magnetic resonance imaging neurofeedback-guided motor imagery training and motor training for Parkinson's Disease: randomized trial [PDF]

, 2016
Objective: Real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback (NF) uses feedback of the patient’s own brain activity to self-regulate brain networks which in turn could lead to a change in behavior and clinical symptoms.
Brosnan, Meadhbh, Busse Morris, Monica, Linden, David E. J., Morris, Huw R., Subramanian, Leena, Turner, Duncan L.   +5 more
core   +3 more sources

Validation of a self‐completed Dystonia Non‐Motor Symptoms Questionnaire

Annals of Clinical and Translational Neurology, 2019
Objective To develop and validate a novel 14‐item self‐completed questionnaire (in English and German) enquiring about the presence of non‐motor symptoms (NMS) during the past month in patients with craniocervical dystonia in an international multicenter
Lisa Klingelhoefer, Kallol R. Chaudhuri, Christoph Kamm, Pablo Martinez‐Martin, Kailash Bhatia, Anna Sauerbier, Maximilian Kaiser, Carmen Rodriguez‐Blazquez, Bettina Balint, Robert Untucht, Lynsey J. Hall, Lauritz Mildenstein, Miriam Wienecke, Davide Martino, Olaf Gregor, Alexander Storch, Heinz Reichmann   +16 more
doaj   +1 more source

Parkinson's Disease Subtypes Identified from Cluster Analysis of Motor and Non-motor Symptoms

Frontiers in Aging Neuroscience, 2017
Parkinson's disease is now considered a complex, multi-peptide, central, and peripheral nervous system disorder with considerable clinical heterogeneity. Non-motor symptoms play a key role in the trajectory of Parkinson's disease, from prodromal premotor
Jesse Mu, Kallol R. Chaudhuri, Concha Bielza, Jesus de Pedro-Cuesta, Pedro Larrañaga, Pablo Martinez-Martin   +5 more
doaj   +1 more source

Clinical Characteristics of Patients with De Novo Parkinson’s Disease and a Positive Family History

Medicina
Background/Objectives: A family history of Parkinson’s disease (PD) is an important risk factor for developing PD. Because only a few studies have investigated the clinical characteristics of PD patients based on family history, this study compared the ...
Hyunsoo Kim, Seong-Min Choi, Hak-Loh Lee, Soo Hyun Cho, Byeong C. Kim   +4 more
doaj   +1 more source

Temporal discrimination: Mechanisms and relevance to adult-onset dystonia [PDF]

, 2017
Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as ...
Beck, Rebecca, Conte, Antonella, Hutchinson, Michael, Killian, Owen, Mcgovern, Eavan M., Narasimham, Shruti, O'Riordan, Sean, Reilly, Richard B.   +7 more
core   +1 more source

Non-Motor Off Symptoms in Parkinson's Disease

Journal of Korean Medical Science, 2009
The aim of this study is to elucidate the clinical spectrum and frequency of non-motor symptoms during off periods (NMOS) in Parkinson's disease (PD) patients with motor fluctuation. We compared clinical characteristics between PD patients with motor symptoms only (M-off) and those with both motor and non-motor symptoms (NM-off) during off periods. The
Cheon, Sang-Myung, Park, Min Jeong, Kim, Wook-Joo, Kim, Jae Woo   +3 more
openaire   +2 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Retrospective analysis of diet and gut microbiota diversity and clinical pharmacology outcomes in patients with Parkinsonism syndrome

Heliyon
Background: Parkinson's disease (PD) is a global neurodegenerative ailment impacting millions, causes significant degeneration of dopaminergic neurons in the substantia nigra. Emerging research underscores the gut microbiota's role in PD onset.
Yunxin Hu, Haoyue Wang, Yongkang Zhong, Yongqi Sun   +3 more
doaj   +1 more source

Parent Quality of Life at Two Years Following Their Child's Completion of Acute Lymphoblastic Leukemia Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Parents of children treated for acute lymphoblastic leukemia (ALL) often experience significant caregiver burden and disruption to their well‐being. While parent quality of life (QoL) during treatment is well characterized, little is known about outcomes during early survivorship.
Sara Dal Pra, Maria McCarthy, Michael Takagi, Cinzia De Luca   +3 more
wiley   +1 more source