Results 71 to 80 of about 335,095 (291)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

The Association between the Use of Proton Pump Inhibitors and the Risk of Hypomagnesemia in a National Cohort of Veteran Patients with HIV

Journal of the International Association of Providers of AIDS Care, 2019
Objectives: To examine the risk of hypomagnesemia of HIV-positive patients adherent to proton pump inhibitors (PPIs). Methods: A cohort study utilizing the Veterans Affairs Informatics and Computing Infrastructure was conducted on patients with (1) a ...
S. Scott Sutton PharmD, Joseph Magagnoli MS, Tammy Cummings PhD, James W. Hardin PhD   +3 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

icenReg: Regression Models for Interval Censored Data in R

Journal of Statistical Software, 2017
The non-parametric maximum likelihood estimator and semi-parametric regression models are fundamental estimators for interval censored data, along with standard fullyparametric regression models.
Clifford Anderson-Bergman
doaj   +1 more source

A comparative analysis on characteristics and mortalities of four key transmission populations on antiretroviral therapy: a retrospective cohort study in Northwest China

BMC Infectious Diseases, 2022
Background This study explored disparities in characteristics and mortalities among four major transmission groups on antiretroviral therapy in northwest China as well as the survival impact of each transmission route.
Shuo Feng, Zirong Zhu, Pengju Yang, Juan Jin, Huihui Tuo, Ning Wang, Ruimin Bai, Yan Sun, Liumei Song, Xiu Zhang, Shengbang Wang, Qiqi Duan, Yingjian Huang, Yan Zheng, Songhua Xu   +14 more
doaj   +1 more source

Analyzing Non-proportional Hazards: Use of the MRH Package

, 2016
In this manuscript we demonstrate the analysis of right-censored survival outcomes using the MRH package in R. The MRH package implements the multi-resolution hazard (MRH) model, which is a Polya-tree based, Bayesian semi-parametric method for flexible estimation of the hazard rate and covariate effects. The package allows for covariates to be included
Hagar, Yolanda, Dukic, Vanja
openaire   +2 more sources

Stratified-extended cox model in survival modeling of non-proportional hazard [PDF]

IOP Conference Series: Earth and Environmental Science, 2019
AbstractCox proportional hazard model is frequently used in survival analysis. Cox proportional hazard model is time independent covariate while many models involve time as a dependent covariate causing incomplete proportional hazard assumption, known as non-proportional hazard.
Asep Saefuddin, Anang Kurnia, I W Mangku, Dewi Juliah Ratnaningsih, Dewi Juliah Ratnaningsih   +4 more
openaire   +1 more source

Multi-Modal Trip Hazard Affordance Detection On Construction Sites

, 2017
Trip hazards are a significant contributor to accidents on construction and manufacturing sites, where over a third of Australian workplace injuries occur [1].
McMahon, Sean, Milford, Michael, Sünderhauf, Niko, Upcroft, Ben   +3 more
core   +2 more sources

Analysis of time-to-event for observational studies: Guidance to the use of intensity models

, 2020
This paper provides guidance for researchers with some mathematical background on the conduct of time-to-event analysis in observational studies based on intensity (hazard) models.
Abrahamowicz, Michal, Andersen, Per Kragh, Cook, Richard J, Joly, Pierre, Martinussen, Torben, Perme, Maja Pohar, Taylor, Jeremy MG, Therneau, Terry M, van Houwelingen, Hans C   +8 more
core   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source