Results 91 to 100 of about 10,385,388 (284)

Antimicrobial Peptides from Marine Proteobacteria

Marine Drugs, 2013
After years of inadequate use and the emergence of multidrug resistant (MDR) strains, the efficiency of “classical” antibiotics has decreased significantly. New drugs to fight MDR strains are urgently needed.
Yannick Fleury, Patrick Le Chevalier, Benjamin Brillet, Eric Balnois, Camille Jégou, Florie Desriac   +5 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Discovery of diverse chimeric peptides in a eukaryotic proteome sets the stage for experimental validation of the mosaic translation hypothesis

Computational and Structural Biotechnology Journal
The high complexity of eukaryotic organisms enabled their evolutionary success, driven by the diversification of their proteomes. Various mechanisms contributed to this process.
Umut Çakır, Noujoud Gabed, Yunus Emre Köroğlu, Selen Kaya, Senjuti Sinharoy, Vagner A. Benedito, Marie Brunet, Xavier Roucou, Igor S. Kryvoruchko   +8 more
doaj   +1 more source

The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria. [PDF]

RSC Med Chem, 2021
Bann SJ, Ballantine RD, Cochrane SA.
europepmc   +1 more source

Probing protein sequences as sources for encrypted antimicrobial peptides [PDF]

, 2012
Starting from the premise that a wealth of potentially biologically active peptides may lurk within proteins, we describe here a methodology to identify putative antimicrobial peptides encrypted in protein sequences.
Francisco J. L. Aragão (132479), Jacques Nicoli (132482), Guilherme D Brand, Tinoco Maria L. P., Guilherme D. Brand (132470), Sharon M Kelly, Maria L P Tinoco, Brand, G.D., Jacques Nicoli, Mariana T. Q. Magalhães (132473), Francisco J L Aragão, Tinoco, M.L.P., Alan Cooper (9827), Cooper Alan, Nicoli, J., Carlos Bloch, Kelly Sharon M., Magalhães, M.T.Q., Sharon M. Kelly (132485), Kelly, S., Aragão, F.J.L., Bloch Jr, C., Brand Guilherme D., Aragão Francisco J. L., Maria L. P. Tinoco (132476), Magalhães Mariana T. Q., Alan Cooper, Bloch Carlos, Cooper, A., Mariana T Q Magalhães, Nicoli Jacques, Carlos Bloch Jr (132488)   +31 more
core   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

De novo design and engineering of non-ribosomal peptide synthetases

, 2018
Peptides derived from non-ribosomal peptide synthetases (NRPSs) represent an important class of pharmaceutically relevant drugs. Methods to generate novel non-ribosomal peptides or to modify peptide natural products in an easy and predictable way are ...
Bode, H., Niesert, C., Wesche, F., Tietze, A., Fleischhacker, F., Linck, A., Bozhueyuek, K.   +6 more
core   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

Peptides to combat viral infectious diseases

, 2020
Viral infectious diseases have resulted in millions of deaths throughout history and have created a significant public healthcare burden. Tremendous efforts have been placed by the scientific communities, health officials and government organizations ...
Pandya, Priyanka, Liu, Jinsha, Ting, Joey Paolo, Ding, Yun, Al-Azzam, Shams, Afshar, Sepideh   +5 more
core   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source