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Genome-Guided Discovery of an Antimicrobial Peptide Scaffold from an Undescribed Antarctic <i>Rhodococcus</i> Lineage: A Proof-of-Concept Study. [PDF]
Int J Mol SciGonzález D +7 more
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Streamlined Chemoenzymatic Synthesis of Cyclic Peptides by Non-ribosomal Peptide Cyclases
Journal of the American Chemical Society, 2023 Macrocyclization improves the pharmaceutical properties of peptides; however, regio- and chemoselective intramolecular cyclizations remain challenging. Here we developed a streamlined chemoenzymatic approach to synthesize cyclic peptides by exploiting non-ribosomal peptide (NRP) cyclases.
Masakazu Kobayashi +3 more
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Computational Design of Novel Non-Ribosomal Peptides [PDF]
, 2019 Non-ribosomal peptide synthetases (NRPSs) are modular enzymatic machines that catalyze the ribosome-independent production of structurally complex small peptides, many of which have important clinical applications as antibiotics, antifungals, and anti-cancer agents.
Farag, Sherif
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ATPase activity of non-ribosomal peptide synthetases
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2004Adenylation domains of non-ribosomal peptide synthetases (NRPS) catalyse the formation of aminoacyl adenylates, and in addition synthesize mono- and dinucleoside polyphosphates. Here, we show that NRPS systems furthermore contain an ATPase activity in the range of up to 2 P(i)/min.
Maja, Pavela-Vrancic +2 more
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Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides
Natural Product Reports, 2023This review summarises the recent studies on the biosynthesis of polyketides, non-ribosomal peptides and their hybrids using isotopic labelling experiments.
Anwei Hou, Jeroen S. Dickschat
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Landornamides: Antiviral Ornithine‐Containing Ribosomal Peptides Discovered through Genome Mining
Angewandte Chemie - International Edition, 2020 International audienceProteusins are a family of bacterial ribosomal peptides that largely remain hypothetical genome-predicted metabolites. The only known members are the polytheona-mide-type cytotoxins, which have complex structures due to numerous ...
Ute Greczmiel +2 more
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Combinatorial Biosynthesis of Non-Ribosomal Peptides
Combinatorial Chemistry & High Throughput Screening, 2003Non-ribosomal peptide synthetases (NRPS) are modular assembly lines catalysing the synthesis of many small peptides in microbes. Genetic replacements of domains or modules in NRPS encoded by gene clusters in Bacillus sp. with corresponding domains or modules from foreign NRPS have led in several cases to the in vivo synthesis of peptides with predicted
Ullrich, Keller, Florian, Schauwecker
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Non-ribosomal peptide antibiotics
Expert Opinion on Therapeutic Patents, 2000Numerous important chemotherapeutic agents are non-ribosomal peptides (NRPs). Synthesised as secondary metabolites, they include a range of antimicrobials and recent work examining the biosynthetic pathways of non-ribosomal peptides suggests that the paths may be manipulated at a molecular genetic level.
David P Mankelow, Brett A Neilan
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Non-ribosomal peptide synthesis
Current Opinion in Cell Biology, 1991Many peptides are synthesized by the multienzyme thiotemplate mechanism. This is catalyzed by large, multifunctional enzymes called peptide synthetases. Recent studies have focused on elucidating the primary structure of the peptide synthetases and defining their functional domains. These are essential first steps in the detailed mutational analysis of
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Structures and mechanism of condensation in non-ribosomal peptide synthesis
NatureNon-ribosomal peptide synthetases (NRPSs) are megaenzymes responsible for the biosynthesis of many clinically important natural products, from early modern medicines (penicillin, bacitracin) to current blockbuster drugs (cubicin, vancomycin) and newly approved therapeutics (rezafungin)1,2.
Angelos Pistofidis +5 more
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