Results 241 to 250 of about 10,385,388 (284)

Non-Ribosomal Peptide Synthetases of Fungi

2009
Non-ribosomal peptide synthetases (NRPSs) are large enzymes which catalyze the assembly of a vast number of complex peptides which often possess interesting properties. The physiological role of non-ribosomally produced peptides is discussed and the organization of NRPSs in fungi is described.
openaire   +1 more source

A dissected non-ribosomal peptide synthetase maintains activity

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Non-ribosomal peptide synthetases (NRPSs) generate chemically complex compounds and their modular architecture suggests that changing their domain organization can predictably alter their products. Ebony, a small three-domain NRPS, catalyzes the formation of β-alanine containing amides from biogenic amines.
Amanda J, Platt, Shae, Padrick, Amy T, Ma, Joris, Beld   +3 more
openaire   +2 more sources

Total synthesis and functional analysis of non‐ribosomal peptides

The Chemical Record, 2011
AbstractAntillatoxin and polytheonamide B are cytotoxic non‐ribosomal peptides, both isolated from marine sources. These molecules possess unique biological activities that relate to ion channel proteins. Antillatoxin binds and activates voltage‐gated sodium channels, while polytheonamide mimics functions of an ion channel protein.
openaire   +2 more sources

[Biosynthesis of peptides: a non-ribosomal system].

Die Naturwissenschaften, 1992
The biosynthesis of peptides in nonribosomal systems is accomplished by complex multienzymes. These multienzymes assemble the required template for the construction of each natural product in the form of linearly coupled modules. This organization principle permits the integration of multistep synthetic processes on a single macromolecule.
H, Kleinkauf, H, van Liempt, H, Palissa, H, von Döhren   +3 more
openaire   +1 more source

Non-ribosomal peptide formation on multifunctional proteins

Trends in Biochemical Sciences, 1983
Abstract Polyenzymes have been found to catalyse the formation of peptides containing non-protein constituents. Such protein templates are multifunctional polypeptides with catalytic sites for amino acid activation, epimerization, modification, peptide elongation and cyclization reactions.
H. Kleinkauf, H. von Do¨hren
openaire   +1 more source

3.7.1 Isoprenoids, Polyketides, and (Non)ribosomal Peptides

2015
AbstractThis chapter describes methods for the biosynthesis and biocatalysis of natural products belonging to the isoprenoids, polyketides (acetate pathway), phenylpropanoids (shikimate pathway), alkaloids, and ribosomal and nonribosomal peptides. Recent advances in genome-sequencing technologies and synthetic biology approaches are discussed, and ...
M. Quin, C. Flynn, J. Ellinger, C. Schmidt-Dannert   +3 more
openaire   +1 more source

[Advances in engineering non-ribosomal peptide synthetase].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2021
Non-ribosomal peptide synthetases catalyze the biosynthesis of structurally and functionally diverse non-ribosomal peptide natural products, which have broad applications in pharmaceutical, agricultural, and industrial sectors. Engineered non-ribosomal peptide synthetases can be used to produce novel non-ribosomal peptides through combinatorial ...
Chen, Wang, Yuquan, Xu
openaire   +1 more source

Non-ribosomal Peptides from Entomogenous Fungi

2015
Entomogenous fungi play a very important role in controlling the natural population of insect pests. Many of them have been developing as myco-insecticides. During evolution, entomogenous fungi acquired lots of pathogenic factors against host insects. Non-ribosomal peptide (NRP) is a usual pathogenic factor of entomogenous fungi.
Qiongbo Hu, Tingyan Dong
openaire   +1 more source

Peptide Bond Formation in Non-ribosomal Systems

1978
Biosynthesis of peptides requires (1) carboxyl group activation, and (2) specific addition of acceptor amino (imino) group. Activation reactions include formation of phosphates (peptidoglycan, glutathione) or of adenylates (aminoacyl-tRNA-ligases, gramicidin S-synthetase).
H. Kleinkauf, H. Koischwitz
openaire   +1 more source

Non-ribosomal peptide biosynthetic systems

2002
The increasing number of pathogenic organisms developing resistance to traditional therapy requires novel concepts for the generation of pharmacologically useful drugs. A wide variety of natural peptides, peptidolactones, and depsipeptides, are synthesised non-ribosomally with the aid of multifunctional peptide synthetases. Several hundred compounds of
openaire   +1 more source