Results 1 to 10 of about 1,454,197 (114)
Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9
IScience, 2020 Many of the proteins produced by SARS-CoV-2 have related counterparts across the Severe Acute Respiratory Syndrome (SARS-CoV) family. One such protein is non-structural protein 9 (Nsp9), which is thought to mediate both viral replication and virulence ...
Dene Littler +2 more
exaly +2 more sources
Communications Biology, 2023 Reporting the crystal structure of the N-terminal domain of the viral nucleocapsid protein in complex with the ubiquitin-like domain 1 of Nsp3 in SARS-CoV ...
Xincheng Ni +4 more
doaj +2 more sources
Roles of Non-Structural Protein 4A in Flavivirus Infection
Viruses, 2021 Infections with viruses in the genus Flavivirus are a worldwide public health problem. These enveloped, positive sense single stranded RNA viruses use a small complement of only 10 encoded proteins and the RNA genome itself to remodel host cells to ...
Paeka Klaitong, Duncan R. Smith
doaj +2 more sources
The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection
International Journal of Molecular Sciences, 2020 Influenza (flu) is a contagious viral disease, which targets the human respiratory tract and spreads throughout the world each year. Every year, influenza infects around 10% of the world population and between 290,000 and 650,000 people die from it ...
Rui M M Brito +2 more
exaly +2 more sources
Microbiology Spectrum, 2022 Remdesivir (RDV) was the first antiviral drug approved by the FDA to treat severe coronavirus disease-2019 (COVID-19) patients. RDV inhibits SARS-CoV-2 replication by stalling the non structural protein 12 (nsp12) subunit of the RNA-dependent RNA ...
Marta Santos Bravo +24 more
doaj +1 more source
SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1
Cell Death and Differentiation, 2022 A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral pathogenicity.
Xiao Sun +27 more
semanticscholar +1 more source
Cell Host and Microbe, 2023 The historically dominant SARS-CoV-2 Delta variant and the currently dominant Omicron variants carry a T492I substitution within the non-structural protein 4 (NSP4).
Xiaoyuan Lin +9 more
semanticscholar +1 more source
Structure, 2023 Non-structural protein 1 (Nsp1) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major virulence factor and thus an attractive drug target.
Ying Wang +3 more
semanticscholar +1 more source
Drug Discovery Today, 2023 Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2), as a highly contagious human pathogen, has infected billions of people worldwide with more than 6 million deaths. With several effective vaccines and antiviral drugs, the SARS-CoV-2
Xin Li, Yongcheng Song
semanticscholar +1 more source
Serological evaluation for the current epidemic situation of foot and mouth disease among cattle and buffaloes in Egypt [PDF]
Veterinary World, 2020 Aim: The present study was aimed to investigate the epidemic situation of foot-and-mouth disease (FMD) in Egypt from 2016 to 2018 based on the detection of FMD virus (FMDV) in carrier or previously infected animals, by determination of antibodies against
Mariam M. Abd El-Rhman +3 more
doaj +1 more source