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Prediction of Protein Function Using Statistically Significant Sub-Structure Discovery [PDF]
, 2007 Proteins perform a vast number of functional roles. The number of protein structures available for analysis continues to grow and, with the development of methods to predict protein structure directly from genetic sequence without imaging technology, the
Lucas, Craig
core +7 more sources
Structural and functional insights into non-structural proteins of coronaviruses [PDF]
Microbial Pathogenesis, 2021 Coronaviruses (CoVs) are causing a number of human and animal diseases because of their zoonotic nature such as Middle East respiratory syndrome (MERS), severe acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19). These viruses can infect respiratory, gastrointestinal, hepatic and central nervous systems of human, livestock, birds,
Rohaim, Mohammed A. +3 more
openaire +2 more sources
Comput. Biol. Medicine, 2021 Background Non-structural protein 1 (Nsp1), a virulence agent of SARS-CoV-2, has emerged as an important target for drug discovery. Nsp1 shuts down the host gene function by associating with the 40S ribosomal subunit. Methods Molecular interactions, drug-
Rahul Singh +3 more
semanticscholar +1 more source
Structure and Non-Structure of Centrosomal Proteins
PLoS ONE, 2013 Here we perform a large-scale study of the structural properties and the expression of proteins that constitute the human Centrosome. Centrosomal proteins tend to be larger than generic human proteins (control set), since their genes contain in average more exons (20.3 versus 14.6).
Dos Santos, Helena G. +24 more
openaire +6 more sources
Foot-and-Mouth Disease Virus Evades Innate Immune Response by 3C-Targeting of MDA5
Cells, 2021 Foot-and-mouth disease (FMD) is a highly contagious disease caused by FMD virus (FMDV) in cloven-hoofed animals. Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are representative receptors in the cytoplasm ...
Hyejin Kim +9 more
doaj +1 more source
Frontiers in Immunology, 2022 Despite autophagy’s pivotal role in the replication of viruses such as duck Tembusu virus (DTMUV), which has caused massive economic losses to the poultry industry in the world, the specific relationships between DTMUV and cellular autophagy remain ...
Jun Zhao +13 more
semanticscholar +1 more source
Molecular diversity, 2022 Novel drug compound hunting was carried out for SARS-CoV-2 proteins with low mutation susceptibility. The probability of escape mutation and drug resistance is lower if conserved microbial proteins are targeted by therapeutic drugs.
Md Nazmus Samdani +4 more
semanticscholar +1 more source
Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection
Virologica Sinica, 2022 Zika virus (ZIKV) evolves non-structural proteins to evade immune response and ensure efficient replication in the host cells. Cholesterol metabolic enzyme 7-dehydrocholesterol reductase (DHCR7) was recently reported to impact innate immune responses in ...
Weijie Chen +10 more
semanticscholar +1 more source
Rotavirus non-structural proteins: structure and function [PDF]
Current Opinion in Virology, 2012 The replication of rotavirus is a complex process that is orchestrated by an exquisite interplay between the rotavirus non-structural and structural proteins. Subsequent to particle entry and genome transcription, the non-structural proteins coordinate and regulate viral mRNA translation and the formation of electron-dense viroplasms that serve as ...
Liya, Hu +4 more
openaire +2 more sources
Targeting SARS-CoV-2 Non-Structural Proteins
International Journal of Molecular Sciences, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly pandemic that has claimed millions of lives worldwide. Like other coronaviruses, the SARS-CoV-2 genome also codes for non-structural proteins (NSPs).
Donald Tam +3 more
openaire +2 more sources