Results 111 to 120 of about 18,387,865 (333)

Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling

Frontiers in Microbiology, 2018
Flaviviruses have evolved complex mechanisms to evade the mammalian host immune systems including the RIG-I (retinoic acid-inducible gene I) like receptor (RLR) signaling.
Jin-Zhu Ma, Harshada Ketkar, T. Geng, E. Lo, Lei-Lei Wang, J. Xi, Qiangming Sun, Zhan-Bo Zhu, Yu-Dong Cui, Long Yang, Penghua Wang   +10 more
semanticscholar   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Different Approaches For Protein Engineering In Industrial Biotechnology [PDF]

, 2011
Protein engineering is the novel field which has wide applications from pharmaceutics, industry, commercial, laundry and research. It may apply rational design or non rational design or both.
Muhammad Waheed Akhtar, Israr Khan
core  

Structural analysis of Salmonella enterica effector protein SopD [PDF]

, 2004
Salmonella outer protein D (SopD) is a type III secreted virulence effector protein from Salmonella enterica. Full-length SopD and SopD lacking 16 amino acids at the N-terminus (SopDDeltaN) have been expressed as fusions with GST in Escherichia coli ...
Williams, C, Gill, A C, Galyov, E E, van den Elsen, J M H, Upadhyay, A, Bagby, S, Wood, M W, Philippe, D L   +7 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Network of Interactions between ZIKA Virus Non-Structural Proteins and Human Host Proteins

Cells, 2020
The Zika virus (ZIKV) is a mosquito-borne Flavivirus and can be transmitted through an infected mosquito bite or through human-to-human interaction by sexual activity, blood transfusion, breastfeeding, or perinatal exposure.
Volha A. Golubeva, Thales C. Nepomuceno, Giuliana de Gregoriis, Rafael D. Mesquita, Xueli Li, Sweta Dash, Patrícia P. Garcez, Guilherme Suarez-Kurtz, Victoria Izumi, John Koomen, Marcelo A. Carvalho, Alvaro N. A. Monteiro   +11 more
doaj   +1 more source

The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last

Viruses, 2018
Alphaviruses encode 4 non-structural proteins (nsPs), most of which have well-understood functions in capping and membrane association (nsP1), polyprotein processing and RNA helicase activity (nsP2) and as RNA-dependent RNA polymerase (nsP4).
Benjamin Götte, Lifeng Liu, G. McInerney   +2 more
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Local structural flexibility drives oligomorphism in computationally designed protein assemblies [PDF]

Many naturally occurring protein assemblies have dynamic structures that allow them to perform specialized functions. For example, clathrin coats adopt a wide variety of architectures to adapt to vesicular cargos of various sizes.
Veesler, David, Bethel, Neville P, Antanasijevic, Aleksandar, King, Neil P., King, Neil P, Twarock, Reidun, Watkins, Andrew M, Borst, Andrew J, Miranda, Marcos C, Watkins, Andrew M., Lai, Szu-Hsueh, Wu, Mengyu, Fatehi, Farzad, Baker, David, Wang, Jing Yang 'John', Heck, Albert J R, Borst, Andrew J., Khmelinskaia, Alena, Ward, Andrew B, Ogohara, Cassandra, Chim, Ho Yeung, Wang, Jing Yang (John), Bethel, Neville P., Mallik, Bhoomika Basu, Miranda, Marcos C., Heck, Albert J.R., Caldwell, Shane, Ward, Andrew B.   +27 more
core   +1 more source

A Dual-Channel Buffer-Free Point-of-Care Electrochemical Biosensor for Concurrent Detection of Yellow Fever NS 1 Antigen and Antibody Proteins in Human Serum Samples

ECS Sensors Plus
In this study, the simultaneous determination of yellow fever antigen and antibody non-structural proteins in human serum samples was accomplished using a dual-channel electrochemical system constructed by adapting a cysteamine- and terephthalaldehyde ...
Lokman Liv, Ecenur Daşdemir
doaj   +1 more source