Results 121 to 130 of about 18,387,865 (333)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

FLORA: a novel method to predict protein function from structure in diverse superfamilies [PDF]

, 2009
Predicting protein function from structure remains an active area of interest, particularly for the structural genomics initiatives where a substantial number of structures are initially solved with little or no functional characterisation.
Dallman Timothy J., Nussinov, R., Oliver C. Redfern, Christine A. Orengo, Sillitoe, I., Dessailly Benoît H., Orengo, C.A., Benoît H Dessailly, Redfern, OC, Timothy J. Dallman, Oliver C Redfern, Benoît H. Dessailly, Dallman, TJ, Dessailly, B.H., Orengo Christine A., Ian Sillitoe, Timothy J Dallman, Sillitoe, I, Redfern Oliver C., Christine A Orengo, Dallman, T.J., Sillitoe Ian, Dessailly, BH, Redfern, O.C., Orengo, CA   +24 more
core   +1 more source

The Dual Role of the Antibody Response Against the Flavivirus Non-structural Protein 1 (NS1) in Protection and Immuno-Pathogenesis

Frontiers in Immunology, 2019
Dengue and Zika viruses are closely related mosquito-borne flaviviruses responsible for major public health problems in tropical and sub-tropical countries.
A. Reyes-Sandoval, J. Ludert
semanticscholar   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription

bioRxiv, 2018
Chikungunya virus (CHIKV) is a re-emerging Alphavirus causing fever, joint pain, skin rash, arthralgia, and occasionally death. Antiviral therapies and/or effective vaccines are urgently required.
Yan-Ni Gao, N. Goonawardane, Joseph C. Ward, A. Tuplin, Mark Harris   +4 more
semanticscholar   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Structural characterisation of pre-processed thermoplastic protein derived from bloodmeal [PDF]

, 2012
Additives are required to convert bloodmeal powder into an extrudable thermoplastic protein-based bioplastic. These include a protein denaturant, a surfactant, a reducing agent and plasticisers.
Verbeek, Casparus Johan R., Lay, Mark C., Bier, James Michael   +2 more
core  

Advancements in the genomic feature of Newcastle disease virus and the multifaceted roles of non-structural proteins V/W in viral replication and pathogenesis

Poultry Science
As a prototype of paramyxovirus, Newcastle disease virus (NDV) is a highly contagious avian pathogen that usually causes substantial economic losses to the global poultry industry.
Yuqi Duan, Guiying Leng, Menglan Liu, Zhiqiang Duan   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation

PLoS Pathogens, 2019
It is known that the non-structural protein (NSs) of Toscana virus (TOSV), an emergent sandfly-borne virus causing meningitis or more severe central nervous system injuries in humans, exerts its function triggering RIG-I for degradation in a proteasome ...
Gianni Gori Savellini, Gabriele Anichini, C. Gandolfo, S. Prathyumnan, M. Cusi   +4 more
semanticscholar   +1 more source