Results 141 to 150 of about 720,330 (288)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Validation of a health literacy screening tool (REALM) in a UK population with coronary heart disease.

, 2008
BACKGROUND: Health literacy (HL) has been recognized as an important public health issue in other developed countries such as the US. There is currently no HL screening tool valid for use in the UK.
Gomez, GB, Chesnokov, Melanie, Rowlands, Gill, Reid, Fiona, Gomez, Gabriela B, Chesnokov, M, Shaw, A, Reid, F, Rowlands, G, Ussher, M, Shaw, Adrienne, Ibrahim, SY, Ussher, Michael, Ibrahim, Saima Y   +13 more
core   +1 more source

Screening sites for detection of carbapenemase-producers– a retrospective cohort study

Antimicrobial Resistance and Infection Control
While screening the rectal site and urine may be appropriate for detection of carbapenemase-producing Enterobacterales, respiratory samples, throat and wound swabs may increase the sensitivity of screening protocols when aiming to detect colonization ...
Isabelle Vock, Silvio Ragozzino, Pascal Urwyler, Michelle Baumann, Gioele Capoferri, Peter M. Keller, Sarah Tschudin-Sutter   +6 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Curating Suspect Lists for International Non-target Screening Efforts.ppt

, 2018
The NORMAN Network (www.norman-network.com) is a unique network of reference laboratories, research centres and related organisations for monitoring of emerging environmental substances, through European and across the world. Key activities of the network include prioritization of emerging substances and non-target screening.
Williams, Antony, Schymane@Gmail.Com, Slobodník, Jaroslav, Aalizadeh, Reza, Alygizakis, Nikiforos, Hollender, Juliane, Aligizakis, Nikiforos   +6 more
openaire   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Investigating geographic differences in environmental chemical exposures in maternal and cord sera using non-targeted screening and silicone wristbands in California. [PDF]

J Expo Sci Environ Epidemiol, 2023
Goin DE, Abrahamsson D, Wang M, Park JS, Sirota M, Morello-Frosch R, DeMicco E, Trowbridge J, August L, O'Connell S, Ladella S, Zlatnik MG, Woodruff TJ.   +12 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Summary of studies reporting non targeted HIV screening program in emergency departments, using rapid test since 2006.

, 2012
Summary of studies reporting non targeted HIV screening program in emergency departments, using rapid test since 2006.
Jean-Paul Viard (131045), Aurore Delobelle (131027), Sandra Firmin (131023), Enrique Casalino (131008), Christophe Choquet (131012), Jade Ghosn (131072), Guillaume Der Sahakian (131039), Yann-Erick Claessens (2283), Dominique Costagliola (131086), Florence Damond (131019), Françoise Brun-Vézinet (131084), Elisabeth Bouvet (131015), Patrice Nordmann (13461), Pierre Hausfater (84305), Chakib Alloui (131010), Elisabeth Aslangul (131057), Christine Katlama (4926), Olivier Zak Dit Zbar (131051), Agnès Gautheret-Dejean (131081), Olivier Bouchaud (35421), Beatrice Ename Nkoumazok (131033), Tassadit Tahi (131078), Julie Zundel (131067), Bruno Bernot (131009), Anne Krivine (131063), Bruno Riou (30758)   +25 more
core   +1 more source