Results 131 to 140 of about 720,330 (288)

Identification of Differential Metabolites in Chronic Suppurative Otitis Media With Non‐Targeted and Targeted Metabolomics Approach

Smart Medicine
Chronic suppurative otitis media (CSOM) is a leading cause of hearing loss and otorrhea, and when associated with cholesteatoma, it can pose a serious threat to patients' lives.
Lidan Hu, Yifan Zhu, Chengpeng Wu, Xiao Liu, Qi Wang, Yangyiyi Huang, Hongyan Liu, Xiangjun Chen, Wei Wu, Hua Jiang   +9 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Estimates of the eligible population for Australia’s targeted National Lung Cancer Screening Program, 2025–2030

Australia’s National Lung Cancer Screening Program will commence in July 2025, targeted at individuals aged 50–70 years with a 30 pack-year smoking history (equivalent to 20 cigarettes per day for 30 years), who either currently smoke or have quit within
Julia Steinberg, Caruana, M, Weber, MF, Michael David, Karen Canfell, Qingwei Luo, Marianne F Weber, Luo, Q, Fong, KM, Annette McWilliams, Wade, S, Canfell, K, Yue He, Kwun M Fong, Michael Caruana, He, Y, Steinberg, J, Stephen Wade, Preston Ngo, Mcwilliams, A, David, M, Ngo, P   +21 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Non-Targeted Screening of Metabolites in Aqueous-Ethanol Extract from Spiraea hypericifolia (Rosaceae) Using LC-HRMS. [PDF]

Int J Mol Sci, 2023
Kostikova VA, Petrova NV, Shaldaeva TM, Koval VV, Chernonosov AA.   +4 more
europepmc   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Targeted active screening for tuberculosis in Zimbabwe: are field digital chest X-ray ratings reliable?

, 2019
Setting: Fifteen purposively selected districts in Zimbabwe in which targeted active screening for tuberculosis (Tas4TB) was conducted among TB high-risk groups (HRGs).
Ngwenya, M., Kumar, A. M. V., Takarinda, K. C., Timire, C, Sandy, C., Sengai, T., Woznitza, N., Harries, A. D.   +7 more
core   +1 more source

Non-targeted screening and toxicity study of safety risk substances in facial skincare products: Molecular networking and computational toxicology strategy

Journal of Dermatologic Science and Cosmetic Technology
Background: Risk substances in cosmetics have long been associated with adverse reactions. However, as risk substances become more concealed and diversified, conventional targeted analysis methods are no longer sufficient to meet regulatory requirements.
Dong Guo, Yaxiong Liu, Jingwen Liang, Yayang Huang, Yangjie Li, Jihui Fang, Sheng Yin   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Non-targeted screening and characterization of organic pollutants in wastewater from an industrial park in China

Emerging Contaminants
Industrial parks are significant sources of complex water pollution, making it challenging to trace pollutant origins and ensure water quality. This study established a non-targeted screening workflow and compound persistence, mobility, and toxicity (PMT)
Xu Tan, Shanwei Sun, Song Hou, Linlin Wu, Yangwei Bai, Hongbo Xi, Jian Xu, Changsheng Guo   +7 more
doaj   +1 more source