Results 111 to 120 of about 720,330 (288)

Ethnicity : UK colorectal cancer screening pilot : final report [PDF]

27. In summary, the overall evaluation of the UK Pilot has demonstrated that key parameters of test and programme performance observed in randomised studies of FOBt screening can be repeated in population-based pilot programmes.
Orbell, Sheina, Clay, Diane, Szczepura, Ala, Gumber, Anil, Johnson, Mark R. D., HASH(0x55a67fc56988), O'Sullivan, I., Owen, David   +7 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Investigating the potential for expediting diagnosis of ovarian cancer via prompt symptom recognition & "targeted screening"

, 2009
PhDThis thesis explores the potential for using symptoms as a tool to bring forward the diagnosis of ovarian cancer. Current evidence supports the existence of prediagnostic symptoms, however symptom lead time has yet to be adequately quantified ...
Lim, Anita Wey Wey
core  

Impact of a national HPV vaccination programme for preadolescent girls on cytology screening performance and CIN2+ incidence: five-year population-based cervical screening results from SloveniaResearch in context

The Lancet Regional Health. Europe
Summary: Background: HPV vaccination is most efficacious in preventing cervical cancer and its precursors when administered during preadolescence. Because in Slovenia women are invited for cytology screening from age 20, women targeted for preadolescent
Abyan Irzaldy, Tine Jerman, Inge M.C.M. de Kok, Jan A.C. Hontelez, Harry J. de Koning, Erik E.L. Jansen, Urška Ivanuš   +6 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Non-targeted crystal phase screening strategy and Rietveld refinement application based on complex dust samples in occupational settings

环境与职业医学
BackgroundOccupational health places often involve complex dust samples characterized by diverse compositions and a lack of prior supplementary information.
Ruijie LIANG, Lingyi WEI, Chaoye SHEN
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Target Determination of Volatile Fluoroalkyl Pollutants and Non-Target Screening for Environmental Monitoring

Talanta
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants known for their toxicity, mobility, and bioaccumulation. Efficient sample preparation and analysis of these compounds are critical for environmental monitoring. In this study, a novel analytical methodology is presented, integrating dynamic headspace extraction (DHS ...
Maria Chiara Corviseri, Allan Polidoro, Marco De Poli, Claudia Stevanin, Tatiana Chenet, Caterina D'Anna, Alberto Cavazzini, Luisa Pasti, Flavio Antonio Franchina   +8 more
openaire   +3 more sources

Integrating cervical cancer screening and HPV vaccination: a pilot experience in the Apulia region of Italy

, 2018
The aim of this study was to describe preliminary performance indicators of the cervical cancer screening and HPV vaccination integrated strategy, offered to women aged 25 years residing in the province of Foggia (Apulia, Italy).
Martinelli, D., Fortunato, F., Local gatekeepers and contact points for vaccinations and screening, Cappelli, MG., Prato, R.   +4 more
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source