Results 91 to 100 of about 720,330 (288)

Estimating attendance for breast cancer screening in ethnic groups in London. [PDF]

, 2010
BACKGROUND: Breast screening uptake in London is below the Government's target of 70% and we investigate whether ethnicity affects this. Information on the ethnicity for the individual women invited is unavailable, so we use an area-based method similar ...
Jack, Ruth H, Dixon Steve, Jack Ruth H, Dixon, Steve, Elizabeth A Davies, Renshaw, Christine, Jack, Ruth H., Davies, Elizabeth A.; id_orcid, Henrik Møller, Møller Henrik, Renshaw Christine, Møller, Henrik, Steve Dixon, Christine Renshaw, Moller, Henrik; id_orcid, Ruth H Jack, Davies Elizabeth A, Davies, Elizabeth A   +17 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An improved PCR strategy for fast screening of specific and random integrations in rAAV-mediated gene targeted cell clones

BMC Research Notes, 2011
Background Gene targeting by homologous recombination using recombinant adeno-associated virus (rAAV) is becoming a useful tool for basic research and therapeutic applications due to the remarkably high targeting frequency of rAAV virus vectors. However,
Sørensen Charlotte B, Bolund Lars, Luo Yonglun   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Screening for diabetes in optometric practice [PDF]

, 2010
Diabetes is an increasing problem worldwide and is placing increasing strain on the healthcare system. It often goes undiagnosed for many years until complications occur.
HOWSE, JENNIFER,HELEN, Howse, Jennifer Helen, Howse, Jen   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A review of suspect and non-target screening of agriculture-related organic contaminants

Analytica Chimica Acta
Production systems that aim to reduce waste and promote the reuse of materials contribute to more sustainable food systems. However, these approaches can also lead to the accumulation and recirculation of chemical hazards from organic waste to the soil and, ultimately, to food.
Vergara-Luis, Irantzu, Righetti, Laura, Olivares, Maitane, Padilla-Gonzalez, Federico, Prieto, Ailette, Arrizabalaga Larrañaga, Ane, Ayala-Cabrera, Juan F.   +6 more
openaire   +2 more sources

Evaluating changes in women's attitudes towards cervical screening following a screening promotion campaign and a free vaccination program. CHERE Working Paper 2009/3 [PDF]

This study examines behavioural changes brought about by two interventions introduced to lower the incidence of cervical cancer in Australia. The first intervention is a media campaign promoting regular screening behaviour to women.
Marion Haas, Denzil Fiebig, Meliyanni Johar, Rosalie Viney   +3 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source