Results 51 to 60 of about 720,330 (288)

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Screening attendance, age group and diabetic retinopathy level at first screen [PDF]

, 2016
AIMS: To report on the relationships between age at diagnosis of diabetes, time from registration with the screening programme to first diabetic eye screening and severity of diabetic retinopathy.
Bachmann, M.O., Bachmann, M O, I. M. Stratton, Leese, G.P., Ferguson, B, Jones, C., the Four Nations Diabetic Retinopathy Screening Study Group, Leese, G. P., M. O. Bachmann, Scanlon, P.H., G. P. Leese, Stratton, I.M., Ferguson, B., Scanlon, P. H., Leese, G P, Land, M., B Ferguson, Stratton, I M, C. Jones, M. Land, Stratton, I. M., Land, M, P. H. Scanlon, Jones, C, Bachmann, M. O., Scanlon, Peter H   +25 more
core   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Clinical Epidemiology of Microinvasive Cervical Carcinoma in an Italian Population Targeted by a Screening Programme

, 2022
SIMPLE SUMMARY: According to this population-based study, 3750 patients living in the Emilia-Romagna Region (northern Italy) were registered with cervical carcinoma between 1995–2016, including 2942 eligible patients.
Lauro Bucchi, Ferretti, Stefano, Falcini, Fabio, Campari, Cinzia, Fabio Falcini, Giorgi Rossi, Paolo, Ravaioli, Alessandra, Alessandra Ravaioli, Vattiato, Rosa, Priscilla Sassoli de Bianchi, Costa, Silvano, Zamagni, Federica, On Behalf Of The Emilia-Romagna Region Workgroup For Cervical Screening Evaluation, null, Silvia Mancini, Orietta Giuliani, Debora Canuti, Mancini, Silvia, Cinzia Campari, Flavia Baldacchini, Giuliani, Orietta, Canuti, Debora, Stefano Ferretti, Sassoli de Bianchi, Priscilla, Federica Zamagni, Bucchi, Lauro, Rosa Vattiato, Silvano Costa, on behalf of the Emilia-Romagna Region Workgroup for Cervical Screening Evaluation on behalf of the Emilia-Romagna Region Workgroup for Cervical Screening Evaluation, Paolo Giorgi Rossi, Baldacchini, Flavia   +29 more
core   +1 more source

“MS-Ready” structures for non-targeted high-resolution mass spectrometry screening studies

Journal of Cheminformatics, 2018
Chemical database searching has become a fixture in many non-targeted identification workflows based on high-resolution mass spectrometry (HRMS). However, the form of a chemical structure observed in HRMS does not always match the form stored in a ...
Andrew D. McEachran, Kamel Mansouri, Chris Grulke, Emma L. Schymanski, Christoph Ruttkies, Antony J. Williams   +5 more
doaj   +1 more source

Antibiotics and Non-Targeted Metabolite Residues Detection as a Comprehensive Approach toward Food Safety in Raw Milk

Foods, 2021
Antibiotic residues in milk are a serious health and technological problem in dairy processes. This study aims to verify the absence of administered antimicrobials after therapeutic treatments, taking into consideration the withdrawal period, and to ...
Luca Maria Chiesa, Federica Di Cesare, Maria Nobile, Roberto Villa, Lucia Decastelli, Francesca Martucci, Mauro Fontana, Radmila Pavlovic, Francesco Arioli, Sara Panseri   +9 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Targeted HIV screening in the emergency department [PDF]

, 2021
Despite considerable improvement in human immunodeficiency virus (HIV) knowledge and treatment in the last 3 decades, the overall number of people living with HIV (PLHIV) is still rising with up to one quarter being unaware of their HIV status. Early HIV
Spagnolello O., Spagnolello, Ornella, Reed, Matthew J.; id_orcid, Reed M. J.   +3 more
core   +1 more source

Young people’s perspectives of thyroid cancer screening and its harms after the nuclear accident in Fukushima Prefecture: a questionnaire survey indicating opt-out screening strategy of the thyroid examination as an ethical issue

BMC Cancer, 2022
Background Overdiagnosis of thyroid cancer has become a major global medical issue. Ultrasound-based thyroid cancer screening has promoted overdiagnosis, and recently international recommendations state that it should not be conducted, even after a ...
Sanae Midorikawa, Akira Ohtsuru
doaj   +1 more source