Results 111 to 120 of about 78,820 (216)

Differentially expressed genes and therapeutic targets for nonalcoholic fatty liver disease from transcriptomic techniques. [PDF]

Medicine (Baltimore)
Li J, Li Y, Zhang Y, Zhang S.
europepmc   +1 more source

Combination of 3D Micro Contact Printing and Scraping Technique for Site Selective Cocultivation Across a Porous Micro Structured Scaffold

Small, EarlyView.
The study by Brauer et al. presents an operationally simple scraping technique in combination with 3D‐µCP to generate 3D cell patterns on both, front and the reverse side of a micro thermoformed substrate. It can be used to study cell‐to‐cell crosstalk at the microlevel with topographies similar to real tissue. Abstract 3D‐microcontact printing (3D‐µCP)
Dana Brauer, Anni Peng, Justyna Borowiec, Jörg Hampl, Shannon Prehl, Maren Klett, Merle Johanna Küstner, Frank Weise, Andreas Schober, Sukhdeep Singh   +9 more
wiley   +1 more source

miRNAs, lncRNAs, circRNAs and piRNAs in Nonalcoholic Fatty Liver Disease: Past, Present and Future. [PDF]

Int J Mol Sci
Lucaciu RL, Orasan OH, Hangan AC, Iancu M, Cozma A, Coste SC, Gog-Bogdan S, Sevastre B, Procopciuc LM.   +8 more
europepmc   +1 more source

Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini‐Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim Medical gases, including nitric oxide, carbon monoxide, hydrogen sulphide and molecular hydrogen, have emerged as key regulators of redox balance and cellular signalling. This mini‐review examines their relevance to paediatric endocrine and neurodevelopmental pathways, domains particularly sensitive to oxidative and inflammatory ...
Roberto Paparella, Fabiola Panvino, Ida Pucarelli, Luigi Tarani   +3 more
wiley   +1 more source

Application of probiotic therapy in nonalcoholic fatty liver disease: mediating mechanism and future perspective. [PDF]

Front Cell Infect Microbiol
Luo XY, Huang WB, Lu CH, Gu W, Feng ZX, Shen S, Chen MZ, Zheng SS, Yang Z.   +8 more
europepmc   +1 more source

Exploration of Multiple Non‐Invasive Tests for Assessing Response to Treatment in a Semaglutide Phase 2b Trial in Patients with MASH

Alimentary Pharmacology &Therapeutics, EarlyView.
This study investigated multiple non‐invasive tests (NIT) in a phase 2b study of patients with MASH and fibrosis treated with semaglutide. Findings revealed that semaglutide significantly improved NIT scores versus placebo from as early as 28 weeks. The results support the use of NITs to assess a treatment response to semaglutide.
Louise Maymann Nitze, Vlad Ratziu, Arun J. Sanyal, Vincent Wai‐Sun Wong, Clare Balendran, Jan Fleckner, Mette Skalshøi Kjær, Niels Krarup, Quentin M. Anstee   +8 more
wiley   +1 more source

Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring

Cell Proliferation, EarlyView.
Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo, Zexin Yang, Junsen She, Chen Fang, Yizhi Hu, Hefeng Huang, Ling Gao   +6 more
wiley   +1 more source

Predictive role of lactate dehydrogenase-to-albumin ratio (LAR) in nonalcoholic fatty liver disease and advanced liver fibrosis. [PDF]

Medicine (Baltimore)
Li G, He T, Geng M, Hong S, Qi F.
europepmc   +1 more source

Unveiling the Crucial Nexus: Mitochondrial Quality Control as a Central Driver in Metabolic Dysfunction‐Associated Steatotic Liver Disease Pathogenesis

Cell Proliferation, EarlyView.
Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu, Junqi Wang, Nan Lu, Zhijiang Guo, Sang‐Bing Ong, Yong Gao, Hao Zhou, Xing Chang, Miao Meng   +8 more
wiley   +1 more source

Influence of an internet-based proactive follow-up management model on the prognosis of nonalcoholic fatty liver disease. [PDF]

World J Gastroenterol
Liu SY, Gao GF, Wang XY, Yu J.
europepmc   +1 more source