Results 91 to 100 of about 954,120 (303)

A novel noncoding RNA processed by Drosha is restricted to nucleus in mouse

, 2008
Noncoding RNAs constitute a huge repertoire of gene regulatory molecules. Our previous, fine-resolution characterization of a mouse meiotic recombination hotspot from chromosome 8 resulted in identification of 2.4-kb unspliced and polyadenylated ...
Rao, Satyanarayana MR, Ganesan, Gayatri
core  

Chromosome fusions triggered by noncoding RNA

, 2016
Chromosomal fusions are common in normal and cancer cells and can produce aberrant gene products that promote transformation. The mechanisms driving these fusions are poorly understood, but recurrent fusions are widespread.
Bracht, John R, John R. Bracht (277573), Keerthi Shetty (2819902), Nowacki, Mariusz, Derek M. Clay (2819890), Grace J. Uttarotai (2819887), Wang, Xing, Xiao Chen (260187), Chen, Xiao, Sierra S. McCloud (2819899), Wang, Jingmei, Shetty, Keerthi, Laura F. Landweber (19272), Callihan, Evan C, Uttarotai, Grace J, Clay, Derek M, Evan C. Callihan (2819893), Xing Wang (154377), Jingmei Wang (2819896), Landweber, Laura F, Mariusz Nowacki (129438), McCloud, Sierra S, Callihan EC, Wang J, Nowacki M, Bracht JR, Clay DM, Wang X, Chen X, McCloud SS, Shetty K, Landweber LF, Uttarotai GJ   +32 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Primary Cilia Formation Mediated by Hsa_Circ_0005185/OTUB1/RAB8A Complex Inhibits Prostate Cancer Progression by Suppressing Hedgehog Signaling Pathway

Advanced Science
Prostate cancer (PCa) is one of the most common malignancies for male individuals globally. Androgen deprivation therapy (ADT) initially demonstrated significant efficacy in treating PCa; however, most cases of PCa eventually progress to castration ...
Aoyu Fan, Yunyan Zhang, Yunpeng Li, Wei Meng, Fan Wu, Wei Pan, Zhongliang Ma, Wei Chen   +7 more
doaj   +1 more source

A Computational Model to Predict the Causal miRNAs for Diseases

Frontiers in Genetics, 2019
MicroRNAs (miRNAs) are one class of important noncoding RNA molecules, and their dysfunction is associated with a number of diseases. Currently, a series of databases and algorithms have been developed for dissecting human miRNA–disease associations ...
Yuanxu Gao, Kaiwen Jia, Jiangcheng Shi, Yuan Zhou, Qinghua Cui, Qinghua Cui   +5 more
doaj   +1 more source

Landscape of Noncoding RNA in the Hypoxic Tumor Microenvironment

Amidst the prevalent and notable characteristic of a hypoxic microenvironment present in the majority of solid tumors, a burgeoning number of studies have revealed the significance of noncoding RNAs (ncRNAs) in hypoxic tumor regions. The transcriptome of
Gui Qi, Haixia Zhang, Lianfeng Gong, Fei Yang, Zhaowu Ma, Chuanxin Zou   +5 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Pseudouridylation of Epstein-Barr Virus Noncoding RNA EBER2 Facilitates Lytic Replication

, 2022
International audienceEpstein-Barr virus (EBV) expresses two highly-abundant noncoding RNAs called EBV-encoded RNA 1 (EBER1) and EBER2, which are preserved in all clinical isolates of EBV, thus underscoring their essential function in the viral life ...
Henry, Belle, Schlegel, Brent, Helm, Mark, Lee, Nara, Marchand, Virginie, Motorin, Yuri   +5 more
core   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells

, 2016
Wei Liu, Jun Ma, Yong Cheng, Hongbo Zhang, Wengguang Luo, Hongyan Zhang Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People’s Republic of China Abstract: Recently, accumulating evidence has suggested that long ...
Zhang H, Luo W, Ma J, Cheng Y, Liu W
core