Results 111 to 120 of about 954,120 (303)

Advances in α-Lipoic Acid for Disease Prevention: Mechanisms and Therapeutic Insights

Molecules
α-Lipoic acid (ALA) is a naturally occurring compound with diverse biological functions, widely distributed in animal and plant tissues. It has attracted considerable attention due to its versatile therapeutic potential.
Yonglian Wang, Shuxia Jiang, Yaoxuan He, Ping Pang, Hongli Shan   +4 more
doaj   +1 more source

Long Noncoding RNA Maternally Expressed Gene 3 Is Downregulated, and Its Insufficiency Correlates With Poor-Risk Stratification, Worse Treatment Response, as Well as Unfavorable Survival Data in Patients With Acute Myeloid Leukemia

Technology in Cancer Research & Treatment, 2020
Objective: Our study aimed to investigate the correlation of long noncoding RNA maternally expressed gene 3 expression with clinical features, treatment response, and survival profiles in patients with acute myeloid leukemia. Methods: Bone marrow samples
Chunling He MM, Xinmei Wang MM, Jing Luo MM, Yinghua Ma MM, Zhen Yang MM   +4 more
doaj   +1 more source

Algorithms for RNA secondary structure analysis : prediction of pseudoknots and the consensus shapes approach [PDF]

, 2007
Reeder J. Algorithms for RNA secondary structure analysis : prediction of pseudoknots and the consensus shapes approach. Bielefeld (Germany): Bielefeld University; 2007.Our understanding of the role of RNA has undergone a major change in the last decade.
Reeder, Jens
core  

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Ferroptosis: Therapeutic Potential and Strategies in Non-Small Cell Lung Cancer

Biology
Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer and a leading cause of cancer-related morbidity and mortality worldwide. Despite advancements in therapeutic strategies, the prognosis for NSCLC patients remains unfavorable ...
Ying Lei, Shuxia Jiang, Chengyu Kong, Ping Pang, Hongli Shan   +4 more
doaj   +1 more source

Long Noncoding RNA: Genome Organization and Mechanism of Action

, 2017
For the last four decades, we have known that noncoding RNAs maintain critical housekeeping functions such as transcription, RNA processing, and translation.
Debosree Pal, Pal, D., Kanduri, Chandrasekhar,, Chandrasekhar Kanduri, Vijay Suresh Akhade, Akhade, Vijay Suresh,   +5 more
core   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Roles of noncoding RNAs in neuropathic pain

PAIN Reports
. Neuropathic pain is caused by a lesion or disease of the somatosensory (peripheral or central) nervous system. Most patients are associated with persistent or intermittent spontaneous pain.
Ziyi Guo, Jianhua Qiu, Wei Meng, Yanli Li, Haibin Wang   +4 more
doaj   +1 more source

Noncoding RNA-associated competing endogenous RNA networks in trastuzumab-induced cardiotoxicity [PDF]

Trastuzumab-induced cardiotoxicity (TIC) is a common and serious disease with abnormal cardiac function. Accumulating evidence has indicated certain non-coding RNAs (ncRNAs), functioning as competing endogenous RNAs (ceRNAs), impacting the progression of
Bikui Zhang, Nan Su, Yuanying Yang, Yang, Y, Xie, S, Jian Liu, Shanshan Wei, Wenqun Li, Zijun Xiao, Wei, S, Liu, J, Zhang, B, Suifen Xie, Ni Zhou, Li, W, Zhou, N, Xiao, Z, Su, N   +17 more
core   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source