Results 101 to 110 of about 889,978 (256)

Landscape of Noncoding RNA in the Hypoxic Tumor Microenvironment

Amidst the prevalent and notable characteristic of a hypoxic microenvironment present in the majority of solid tumors, a burgeoning number of studies have revealed the significance of noncoding RNAs (ncRNAs) in hypoxic tumor regions. The transcriptome of
Gui Qi, Haixia Zhang, Lianfeng Gong, Fei Yang, Zhaowu Ma, Chuanxin Zou   +5 more
core   +1 more source

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

A novel noncoding RNA processed by Drosha is restricted to nucleus in mouse

, 2008
Noncoding RNAs constitute a huge repertoire of gene regulatory molecules. Our previous, fine-resolution characterization of a mouse meiotic recombination hotspot from chromosome 8 resulted in identification of 2.4-kb unspliced and polyadenylated ...
Rao, Satyanarayana MR, Ganesan, Gayatri
core  

Noncoding RNA-associated competing endogenous RNA networks in trastuzumab-induced cardiotoxicity [PDF]

Trastuzumab-induced cardiotoxicity (TIC) is a common and serious disease with abnormal cardiac function. Accumulating evidence has indicated certain non-coding RNAs (ncRNAs), functioning as competing endogenous RNAs (ceRNAs), impacting the progression of
Bikui Zhang, Nan Su, Yuanying Yang, Yang, Y, Xie, S, Jian Liu, Shanshan Wei, Wenqun Li, Zijun Xiao, Wei, S, Liu, J, Zhang, B, Suifen Xie, Ni Zhou, Li, W, Zhou, N, Xiao, Z, Su, N   +17 more
core   +1 more source

Roles of noncoding RNAs in neuropathic pain

PAIN Reports
. Neuropathic pain is caused by a lesion or disease of the somatosensory (peripheral or central) nervous system. Most patients are associated with persistent or intermittent spontaneous pain.
Ziyi Guo, Jianhua Qiu, Wei Meng, Yanli Li, Haibin Wang   +4 more
doaj   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells

, 2016
Wei Liu, Jun Ma, Yong Cheng, Hongbo Zhang, Wengguang Luo, Hongyan Zhang Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People’s Republic of China Abstract: Recently, accumulating evidence has suggested that long ...
Zhang H, Luo W, Ma J, Cheng Y, Liu W
core  

Noncoding RNA in Mycobacteria.

, 2014
Efforts to understand the molecular basis of mycobacterial gene regulation are dominated by a protein-centric view. However, there is a growing appreciation that noncoding RNA, i.e., RNA that is not translated, plays a role in a wide variety of molecular
Young, Douglas B, Cortes, Teresa, Arnvig, Kristine B   +2 more
core   +1 more source

Advanced Nanomedicine Delivery Systems for Cardiovascular Diseases: Viral and Non-Viral Strategies in Targeted Therapy

Molecules
Cardiovascular diseases (CVDs) represent a leading global health crisis, significantly impairing patients’ quality of life and posing substantial risks to their survival.
Qian Chen, Tong Yu, Jingyi Gong, Hongli Shan   +3 more
doaj   +1 more source