Results 101 to 110 of about 954,120 (303)
, 2012 Long noncoding RNA candidates identified above were classified into four different subsets based on alignment with small RNA databases including microRNA sequences (miRNA), short hairpin forming RNA sequences (shRNA),small interfering RNA sequences ...
Karen M. McGinnis (113006) +1 more
core +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Long noncoding RNA KCNMB2-AS1 acts as an oncogene in ovarian cancer
Acta Biochimica et Biophysica Sinica, 2023 Cao Siyu, Liu Min, Guo Ziyi, Li Yanli
doaj +1 more source
Behavioural Neurology, 2020 Background. The aim of this study was to explore the role of hesperadin in intracerebral hemorrhage (ICH) mice, with the involvement of the mammalian ste20-like kinase 4 (MST4)/AKT signaling pathway. Methods.
Xiaodong Wu +7 more
doaj +1 more source
Advanced Science, EarlyView.The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang +12 more
wiley +1 more source
Tumor‐associated exosomes in cancer progression and therapeutic targets
MedCommExosomes are small membrane vesicles that are released by cells into the extracellular environment. Tumor‐associated exosomes (TAEs) are extracellular vesicles that play a significant role in cancer progression by mediating intercellular communication ...
Xiaomin Liu +8 more
doaj +1 more source
Vernalization-Mediated Epigenetic Silencing by a Long Intronic Noncoding RNA
, 2011 Spring flowering enabled by a winter chill is regulated by interplay between protein-coding and noncoding RNA transcripts.
Jae Bok Heo, Sibum Sung
core +1 more source
Advanced Science, EarlyView.An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang +7 more
wiley +1 more source
dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins
Angewandte Chemie, EarlyView.Double‐stranded RNA (dsRNA) plays an important role in the innate immune system, but can be misregulated in disease, leading to inflammation. Despite the importance of this motif, methods for detecting dsRNA remain limited. This work shows that ADAR3 can be repurposed to provide improved detection of dsRNA, which is demonstrated in the context of viral
Weina Cheng +7 more
wiley +2 more sources