The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma
Acta Biochimica et Biophysica Sinica, 2023 Hepatocellular carcinoma (HCC) is the leading fatal malignancy worldwide. The tumor microenvironment (TME) can affect the survival, proliferation, migration, and even dormancy of cancer cells.
Yang Qianqian +4 more
doaj +1 more source
Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi-Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin. [PDF]
Adv Sci (Weinh)Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yao Y +5 more
europepmc +2 more sources
Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses:Implications for virus evolution and host persistence [PDF]
, 2004 Discrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and ...
Evans, David J +5 more
core +1 more source
A new synthetic protocol for coumarin amino acid
Beilstein Journal of Organic Chemistry, 2013 The hydrochloride of the racemic amino acid (2-(7-hydroxycoumarin-4-yl)ethyl)glycine, which can serve as a fluorescent probe in proteins, and two halogen derivatives of it, were synthesized by using a new synthetic protocol in five steps.
Xinyi Xu, Xiaosong Hu, Jiangyun Wang
doaj +1 more source
A comparative analysis of lncRNAs in prostate cancer exosomes and their parental cell lines
Genomics Data, 2016 Prostate cancer is the second leading cancer in men world-wide. Due to its heterogeneous nature, a considerable amount of research effort has been dedicated in identifying effective clinical biomarkers with a focus on proteins, messenger RNA and ...
Alireza Ahadi +3 more
doaj +1 more source
Structural insights into the dynamics and function of the C-terminus of the E. coli RNA chaperone Hfq [PDF]
, 2011 The hexameric Escherichia coli RNA chaperone Hfq (Hfq(Ec)) is involved in riboregulation of target mRNAs by small trans-encoded RNAs. Hfq proteins of different bacteria comprise an evolutionarily conserved core, whereas the C-terminus is variable in ...
Beich-Frandsen, Mads (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna) +46 more
core +1 more source
p53/MicroRNA-34 axis in cancer and beyond
Heliyon, 2023 Cancer is serious endangers human life. After a long period of research and accumulation, people's understanding of cancer and the corresponding treatment methods are constantly developing. p53 is an important tumor suppressor gene.
Wei Pan +4 more
doaj +1 more source
Distinct MicroRNA Subcellular Size and Expression Patterns in Human Cancer Cells
International Journal of Cell Biology, 2012 Introduction. Small noncoding RNAs have important regulatory functions in different cell pathways. It is believed that most of them mainly play role in gene post-transcriptional regulation in the cytoplasm.
Beibei Chen +5 more
doaj +1 more source
Patterns of selective constraints in noncoding DNA of rice [PDF]
, 2007 Background Several studies have investigated the relationships between selective constraints in introns and their length, GC content and location within genes. To date, however, no such investigation has been done in plants.
Peter D Keightley +11 more
core +1 more source
Microprocessor Activity Controls Differential miRNA Biogenesis In Vivo
Cell Reports, 2014 In miRNA biogenesis, pri-miRNA transcripts are converted into pre-miRNA hairpins. The in vivo properties of this process remain enigmatic. Here, we determine in vivo transcriptome-wide pri-miRNA processing using next-generation sequencing of chromatin ...
Thomas Conrad +3 more
doaj +1 more source