Results 191 to 200 of about 243,847 (257)

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

From In Silico to Clinic: Harnessing Noncoding RNAs for Diabetes Research and Therapy, a Step toward ncRNA Precision. [PDF]

ACS Pharmacol Transl Sci
Hamdy NM, El-Daly SM, Elazazy O, Kabel AM, Salama RM, Gouhar SA, Sallam AM, Darwish SF.   +7 more
europepmc   +1 more source

Long noncoding RNAs in tumor stemness: emerging mechanisms and therapeutic opportunities. [PDF]

Front Genet
Reis EM, Bassères DS.
europepmc   +1 more source

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

P22 Small Noncoding RNAs Are Actively Secreted in <i>Salmonella</i> Outer Membrane Vesicles During Bacteriophage Infection. [PDF]

Noncoding RNA
Naaz S, Kominek HA, Hayes-Guastella LA, McDaniel AM, Alsatari ES, Haastrup AI, Clark OG, Katerski DM, Prinsloo FO, Roberts OR, Shaddix MA, Sullivan BN, Swan IM, Hartsell EM, DeMeis JD, Patil SS, Pham RH, Cox MR, Borchert GM.   +18 more
europepmc   +1 more source

A Novel Plasma Biomarker hsa_circ_0080018 Drives DLBCL Progression via M2 Polarization of Tumor‐Associated Macrophages

Cancer Science, EarlyView.
The proposed mechanistic model in this study. ABSTRACT Noncoding RNAs, including circular RNAs (circRNAs), have been demonstrated to play vital roles in tumorigenesis. Uncovering the functions of circRNAs in tumorigenesis and their underlying regulatory mechanisms may suggest new approaches to the development of novel diagnostic and therapeutic ...
Yanfeng Liu, Yanan Gao, Chuanli Zhao
wiley   +1 more source

Protein Functional Effector (pfe) Noncoding RNAS Are Identical to Fragments from Various Noncoding RNAs. [PDF]

Int J Mol Sci
Patarca R, Haseltine WA.
europepmc   +1 more source

Deep Phenotyping in ReNU Syndrome Identifies a Recognizable Age‐Dependent Clinical Trajectory

Clinical Genetics, EarlyView.
Longitudinal evaluation of 11 individuals with ReNU syndrome revealed an age‐dependent multisystem trajectory. This longitudinal description may help clinicians anticipate changing needs in feeding, growth, neurological, visual, communication, behavioral, and orthopedic care. ABSTRACT Pathogenic variants in the noncoding gene RNU4‐2 cause ReNU syndrome,
Nadja Pekkola Pacheco, Malin Kvarnung, Anna Hammarsjö, Daniel Nilsson, Bianca Tesi, Britt Marie Anderlid, Giedre Grigelioniene, Maria Johansson Soller, Liselot van der Laan, Charlotte Willfors, Charlotta Ingvoldstad Malmgren, Anna Lindstrand, Tommy Stödberg, Ann Nordgren, Angelica Maria Delgado‐Vega   +14 more
wiley   +1 more source

Spheroids and organoids to study long noncoding RNAs in cancer: how they could replace animal models. [PDF]

Cancer Metastasis Rev
Capela AM, Pessoa J, Arede H, Bernardes de Jesus B.   +3 more
europepmc   +1 more source