Results 41 to 50 of about 243,847 (257)
International Journal of Genomics, 2018 Discoveries on nonprotein-coding RNAs have induced a paradigm shift in our overall understanding of gene expression and regulation. We now understand that coding and noncoding RNA machinery work in concert to maintain overall homeostasis.
Preethi Krishnan, Sambasivarao Damaraju
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Noncoding RNAs and Cardiac Fibrosis
Reviews in Cardiovascular Medicine, 2023 Myocardial fibrosis is a common pathological feature of various terminal cardiovascular diseases. Progressive fibrosis is the pathological basis for the development and progression of many cardiac arrhythmias and heart failure.
Changyong Wu +4 more
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The Regulation of Ferroptosis by Noncoding RNAs
, 2023 As a novel form of regulated cell death, ferroptosis is characterized by intracellular iron and lipid peroxide accumulation, which is different from other regulated cell death forms morphologically, biochemically, and immunologically.
Xiangnan Zheng, Cen Zhang
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
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Noncoding RNA as a crucial epigenetic modulator in the degeneration of the ligamentum flavum
Experimental and Molecular MedicineLigamentum flavum degeneration, including hypertrophy and ossification of the ligamentum flavum, leads to degenerative spinal stenosis in older adults. However, the underlying mechanisms of ligamentum flavum degeneration remain unclear, and therapeutic ...
Yongzhao Zhao +7 more
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Focus on Noncoding RNA Regulation of Plant-Microbe Interactions
Molecular Plant-Microbe Interactions, 2016 Investigations in recent years have uncovered important roles for RNA molecules that do not encode proteins (‘noncoding RNAs’) but which, nevertheless, exert powerful effects on gene expression at both transcriptional and posttranscriptional levels.
John P. Carr, Steven A. Whitham
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Long noncoding RNAs in viral infections
, 2016 Viral infections induce strong modifications in the cell transcriptome. Among the RNAs whose expression is altered by infection are long noncoding RNAs (lncRNAs). LncRNAs are transcripts with potential to function as RNA molecules.
Morris, Kevin V, Fortes, Puri
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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The Study of eIF4E Resin in Purifying Noncoding RNAs
四川大学学报. 自然科学版, 2016 Recent large-scale studies of the human transcriptome suggest that there are much more abundant noncoding transcripts than previously excepted. Many noncoding RNAs in cells lack a canonical poly(A) tail, which suggests that Oligo(dT) resin is not ...
LI Jia, DING Mu-Ran, WU Chuan-Fang
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
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