Results 81 to 90 of about 243,847 (257)

Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer

, 2022
Ling Lu,1,* Qiaoyan Liang,2,* Xinyi Zhang,3 Yumeng Xu,3 Dehua Meng,4 Zhaofeng Liang3 1Child Healthcare Department, the Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 2Health Care Department, People’s ...
Lu L, Meng D, Zhang X, Liang Z, Liang Q, Xu Y   +5 more
core  

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Noncoding RNAs, Emerging Regulators of Skeletal Muscle Development and Diseases

, 2015
A healthy and independent life requires skeletal muscles to maintain optimal function throughout the lifespan, which is in turn dependent on efficient activation of processes that regulate muscle development, homeostasis, and metabolism.
Nie, Mao, Deng, Zhong-Liang, Wang, Da-Zhi, Liu, Jianming   +3 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Tumorigenesis-Related Long Noncoding RNAs and Their Targeting as Therapeutic Approach in Cancer

, 2020
Long noncoding RNAs (lncRNA) are emerging as players in physiological processes and as crucial contributors to pathologic states, especially cancer. The direct contribution of lncRNAs to tumorigenesis has been demonstrated by loss- or gain-of-function ...
Marianna Aprile, Valerio Costa, George Calin, Amelia Cimmino   +3 more
core  

Noncoding RNAs in acute kidney injury

, 2018
Acute kidney injury (AKI) is an important health issue concerning ∼50% of patients treated in intensive care units. AKI mainly occurs after sepsis, acute ischemia, nephrotoxicity, or hypoxia and leads to severe damage of the kidney and to an increased ...
Brandenburger, Timo, Lorenzen, Johan M, Devaux, Yvan, Salgado Somoza, Antonio, Lorenzen JM, Devaux Y, Brandenburger T, Salgado Somoza A   +7 more
core   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Role of noncoding RNA as a pacemaker in cancer stem cell regulation: a review article

Journal of the Egyptian National Cancer Institute
Accumulated evidence supported the crucial role of a tiny population of cells within the tumor called cancer stem cells (CSCs) in cancer origination, and proliferation.
Yasmin M. Attia, Samer A. Tadros, Sally A. Fahim, Doaa M. Badr   +3 more
doaj   +1 more source

Hierarchical genetic networks and noncoding RNAs

, 2010
In eukaryotic cells, many genes are transcribed into noncoding RNAs. Such RNAs may associate with mRNAs and inhibit their translation and facilitate degradation. To clarify what may happen in this case, we propose a kinetic model describing the effect of
Zhdanov, Vladimir,, Zhdanov, Vladimir, Vladimir P. Zhdanov   +2 more
core   +1 more source

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source