Results 61 to 70 of about 9,905 (209)

OPA1 in MC4R Neurons Regulates Dietary Fat Intake and Body Weight in Mice

open access: yesThe FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Soybean oil intake induces OPA1 expression in hypothalamic MC4R neurons, contributing to adaptive regulation of appetite. MC4R neuron‐specific OPA1 deficiency increases soybean oil consumption and leads to obesity, with a more pronounced effect in females.
Shigenobu Matsumura   +10 more
wiley   +1 more source

Compensation Response to Hepatic Gluconeogenesis via β‐Hydroxybutyrylation of FBP1 and PCK1 in Dairy Cows

open access: yesAnimal Research and One Health, Volume 4, Issue 2, Page 198-212, May 2026.
(1) Kbhb modification of FBP1 and PCK1 is involved in regulation of the gluconeogenesis pathway. (2) Kbhb of FBP1 and PCK1 is catalyzed by p300 and removed by HDACs. (3) BHB induced an increase in the enzymatic activity of FBP1 and PCK1 through Kbhb modification at the K43 site of FBP1 and the K191 site of PCK1.
DingPing Feng   +6 more
wiley   +1 more source

Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men

open access: yesJournal of Lipid Research, 2004
This study investigated the incorporation of cis-9,trans-11 conjugated linoleic acid (c9,t11 CLA) and trans-10,cis-12-CLA (t10,c12 CLA) into plasma and peripheral blood mononuclear cell (PBMC) lipids when consumed as supplements highly enriched in these ...
Graham C. Burdge   +11 more
doaj   +1 more source

Nonesterified Fatty Acids and Hepatic Glucose Metabolism in the Conscious Dog [PDF]

open access: yesDiabetes, 2004
We used tracer and arteriovenous difference techniques in conscious dogs to determine the effect of nonesterified fatty acids (NEFAs) on net hepatic glucose uptake (NHGU). The protocol included equilibration ([3-3H]glucose), basal, and two experimental periods (−120 to −30, −30 to 0, 0–120 [period 1], and 120–240 min [period 2], respectively).
Mary Courtney, Moore   +6 more
openaire   +2 more sources

Modulation of monkey small intestinal brush border membrane D-glucose transport by nonesterified fatty acids

open access: yes, 1993
Brush border membranes isolated from monkey intestinal mucosa was found to contain considerable amount of nonesterified fatty acids. Incubation of brush border membranes with fatty acid free albumin selectively removed the free fatty acids more than 80 ...
Balasubramanian, K. A., Ibrahim, S. A.
core   +1 more source

GLP‐1 agonists and the gut microbiome: A bidirectional relationship

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1309-1325, May 2026.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath   +2 more
wiley   +1 more source

Plasma Levels of Free Fatty Acids in Women with Gestational Diabetes and Its Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis

open access: yesJournal of Diabetes Research, 2019
Background. Free fatty acids, also known as nonesterified fatty acids, are proinflammatory molecules that induce insulin resistance in nonpregnant individuals.
Jose Rafael Villafan-Bernal   +9 more
doaj   +1 more source

Fat Oxidation, But Not Subcutaneous Adipose Tissue Lipolysis, Differs Between Males and Females During a Treadmill‐Based Heat Tolerance Test

open access: yesEuropean Journal of Sport Science, Volume 26, Issue 5, May 2026.
ABSTRACT This study aimed to determine whether fat metabolism differs between males and females when exposed to extreme exercise‐heat stress. Physically active males (n = 11, 23 ± 4 years, 81.7 ± 11.8 kg, body fat 16.4 ± 6.6%) and females (n = 13, 25 ± 4 years, 60.4 ± 7.1 kg, 24.4 ± 6.7%) completed a 2‐h exercise‐heat tolerance test (40° $\boldsymbol{{}
Margaret C. Morrissey‐Basler   +6 more
wiley   +1 more source

In vitro study of the incorporation and transport of nonesterified fatty acids into the phospholipids of the red blood cell membranes of cystic fibrosis patients

open access: yes, 1982
The in vitro incorporation and transport of plasma nonesterified fatty acids into phospholipids of red cell membranes have been studied in cystic fibrosis and healthy children.
Mandelbaum, Israel   +13 more
core   +1 more source

Use of Metabotyping to Identify Individuals With Different Triglyceride Response Curves After Intake of High‐Fat Meals

open access: yesMolecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.
We applied a latent class mixed model to cluster individuals based on their postprandial triglyceride response curves after consumption of high‐fat meals. Three clusters with different triglyceride response patterns were identified. This approach holds the potential to be used for identifying metabolically dysfunctional individuals.
Jiaying Hu   +5 more
wiley   +1 more source

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