Results 51 to 60 of about 643,488 (207)

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Circulating Non-Esterified Fatty Acids as Biomarkers for Fat Content and Composition in Pigs

Animals, 2021
Circulating non-esterified fatty acids (NEFA) can reflect the composition of dietary fat or adipose tissues depending on the fasting conditions. Therefore, circulating NEFA may be valuable as biomarkers for meat quality traits, such as intramuscular fat ...
Marc Tor, Francesca Vilaró, Roger Ros-Freixedes, Javier Álvarez-Rodríguez, Lluís Bosch, Sofia Gol, Ramona N. Pena, Josep Reixach, Joan Estany   +8 more
doaj   +1 more source

Myo‐Inositol Supplementation During Lactation in Rats Improves Offspring Metabolic and Cognitive Health and Mitigates Impairments Induced by Maternal and Adult Exposure to an Obesogenic Diet

Food Frontiers, Volume 7, Issue 4, July 2026.
Maternal myo‐inositol supplementation during lactation programs sex and maternal diet‐specific metabolic and cognitive benefits in long‐term offspring and partially mitigates effects of maternal and adult obesogenic diets. Abbreviations: CON (control), WD (western diet), TG (triglycerides), NEFA (non‐esterified fatty acids), GLUT4 (glucose transporter ...
Ana Valle, Bàrbara Reynés, Andreu Palou, Mariona Palou, Catalina Picó   +4 more
wiley   +1 more source

Overestimation of Plasma Nonesterified Fatty Acid Concentrations in Heparinized Blood [PDF]

Circulation, 2004
To the Editor: With much interest have we read the important study on the use of glucose-insulin-potassium (GIK) in diabetic patients undergoing coronary artery bypass grafting by Lazar and coworkers.1 A potential mechanism underlying the beneficial effect of GIK administration includes metabolic modulation of (post)ischemic myocardium.
Visser, Liesbeth, Zuurbier, Coert J., van Wezel, Harry B., van der Vusse, Ger J., Hoek, Frans J.   +4 more
openaire   +2 more sources

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, Volume 13, Issue 31, 4 June 2026.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men

Journal of Lipid Research, 2004
This study investigated the incorporation of cis-9,trans-11 conjugated linoleic acid (c9,t11 CLA) and trans-10,cis-12-CLA (t10,c12 CLA) into plasma and peripheral blood mononuclear cell (PBMC) lipids when consumed as supplements highly enriched in these ...
Graham C. Burdge, Berit Lupoli, Jennifer J. Russell, Sabine Tricon, Samantha Kew, Tapati Banerjee, Kevin J. Shingfield, David E. Beever, Robert F. Grimble, Christine M. Williams, Parveen Yaqoob, Philip C. Calder   +11 more
doaj   +1 more source

Nonesterified Fatty Acids and Hepatic Glucose Metabolism in the Conscious Dog [PDF]

Diabetes, 2004
We used tracer and arteriovenous difference techniques in conscious dogs to determine the effect of nonesterified fatty acids (NEFAs) on net hepatic glucose uptake (NHGU). The protocol included equilibration ([3-3H]glucose), basal, and two experimental periods (−120 to −30, −30 to 0, 0–120 [period 1], and 120–240 min [period 2], respectively).
Mary Courtney, Moore, Shosuke, Satake, Margaret, Lautz, Scott A, Soleimanpour, Doss W, Neal, Marta, Smith, Alan D, Cherrington   +6 more
openaire   +2 more sources

KCNK16 Deficiency Deteriorates Body Growth and Diet‐Independently Decreases Lipid Accumulation in Mice

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Loss of KCNK16 in mice alters β‐cell insulin secretion dynamics leading to increased pancreatic insulin content and decreased circulating IGF‐1. Furthermore, body growth and adiposity were reduced independent of dietary interventions. Despite these changes, overall glucose tolerance and insulin sensitivity remain largely preserved.
Olena Früh, Jennifer Winkler, Jana M. Jäger, Rongwan Sun, Aoxue Liu, Niklas Hegemann, Jana Grune, Atsuyo Ikeda, Andreas Diefenbach, Matthias Schäfer, Uwe Schwahn, Johann Gassenhuber, Klaus Steinmeyer, Joachim Spranger, Knut Mai, Sebastian Brachs   +15 more
wiley   +1 more source

Effects of Shade and Concentrate Supplementation on Heat Tolerance, Metabolic, and Hematological Responses of Holstein Cows in a Semi‐Arid Environment

New Zealand Journal of Agricultural Research, Volume 69, Issue 3, June 2026.
This study evaluated heat tolerance and biochemical and haematological responses of Holstein cows exposed to different environmental conditions (full sun or shade) and feeding regimens (with or without concentrate) in the semi‐arid region of Brazil. Sixteen adult cows were distributed across four treatments.
David Ramos da Rocha, Ana Elisa Custódio Montes Cândido, Aline da Silva Rocha, Stela Antas Urbano, Felipe Pontes Teixeira das Chagas, Ana Beatriz Graciano da Costa, José Fernando Bibiano Melo, Fábio Nunes Lista, Hewerthon David Reis Carneiro Rios, Deise Rejane Silva de Oliveira, Juliana Caroline Santos Santana, João Virgínio Emerenciano Neto   +11 more
wiley   +1 more source