Results 31 to 40 of about 14,056 (218)

Comparative analysis of metabolic and functional cardiac alterations in diet- and genetically induced mouse models of cardiac dysfunction. [PDF]

FEBS J
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Ott C, Baumgarten P, Henning T, Weber D, Wallach I, Grune J, Kintscher U, Holzhütter HG, Grune T, Berndt N.   +9 more
europepmc   +2 more sources

Effect of diet-induced obesity on protein expression in insulin signalling pathways of skeletal muscle in male Wistar rats [PDF]

, 2012
BACKGROUND: The prevalence of diet-induced obesity is increasing globally, and posing significant health problems for millions of people worldwide. Diet-induced obesity is a major contributor to the global pandemic of type 2 diabetes mellitus.
Abubakari, Abdul-Razak, Fatani, Sameer, Itua, Imose, Naderali, Ebrahim K., Thomas, Cecil, Wong, Christopher   +5 more
core   +2 more sources

Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men [PDF]

, 2016
We hypothesized that an increased, incomplete fatty acid beta‐oxidation in mitochondria could be part of the metabolic events leading to insulin resistance and thereby an increased type 2 diabetes risk in low birth weight (LBW) compared with normal birth
A. Vaag, Allan, B. Newgard, Christopher, Brøns, Charlotte, Hellgren, Lars, Ribel-Madsen, Amalie, Ribel-Madsen, Rasmus   +5 more
core   +1 more source

The influence of placental metabolism on fatty acid transfer to the fetus

Journal of Lipid Research, 2017
The factors determining fatty acid transfer across the placenta are not fully understood. This study used a combined experimental and computational modeling approach to explore placental transfer of nonesterified fatty acids and identify the rate ...
Simone Perazzolo, Birgit Hirschmugl, Christian Wadsack, Gernot Desoye, Rohan M. Lewis, Bram G. Sengers   +5 more
doaj   +1 more source

A Lipid-Rich Gestational Diet Predisposes Offspring to Nonalcoholic Fatty Liver Disease: A Potential Sequence of Events [PDF]

, 2014
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. It affects 20%–30% of the US population, and it is increasing worldwide.
Hughes, Alexandria N., Oxford, Julia Thom   +1 more
core   +3 more sources

Overestimation of Plasma Nonesterified Fatty Acid Concentrations in Heparinized Blood [PDF]

Circulation, 2004
To the Editor: With much interest have we read the important study on the use of glucose-insulin-potassium (GIK) in diabetic patients undergoing coronary artery bypass grafting by Lazar and coworkers.1 A potential mechanism underlying the beneficial effect of GIK administration includes metabolic modulation of (post)ischemic myocardium.
Visser, Liesbeth, Zuurbier, Coert J., van Wezel, Harry B., van der Vusse, Ger J., Hoek, Frans J.   +4 more
openaire   +2 more sources

Application of Solid Phase Microextraction for Quantitation of Polyunsaturated Fatty Acids in Biological Fluids [PDF]

, 2014
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher.
Birjandi, Afsoon Pajand, Bojko, Barbara, Mirnaghi, Fatemeh Sadat, Pawliszyn, Janusz, Wąsowicz, Marcin   +4 more
core   +1 more source

Saturated Fats: Time to Assess Their Beneficial Role in a Healthful Diet

Dietetics
Saturated fats are widely seen as undesirable components of a healthy diet, as a result of their illusory association with elevated serum cholesterol. The regulation of serum cholesterol is now better understood and a lack of polyunsaturated fatty acids,
Glen D. Lawrence
doaj   +1 more source

Reformulation initiative for partial replacement of saturated with unsaturated fats in dairy foods attenuates the increase in LDL cholesterol and improves flow-mediated dilatation compared with conventional dairy: the randomized, controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) study [PDF]

, 2020
Background Modifying dairy fat composition by increasing the MUFA content is a potential strategy to reduce dietary SFA intake for cardiovascular disease (CVD) prevention in the population.
Fagan, Colette C., Givens, David I., Grandison, Alistair S., Humphries, David J., Jackson, Kim G., Kliem, Kirsty E., Lovegrove, Julie A., Markey, Oonagh, Todd, Sue, Vasilopoulou, Dafni   +9 more
core   +2 more sources

Effect of different fatty acids on the proliferation and cytokine production of dairy cow peripheral blood mononuclear cells

Journal of Dairy Science, 2022
: During the transition period, dairy cows often experience negative energy balance, which induces metabolic and immunological disturbances. Our previous work has shown a relationship between the inhibition of immune functions and increased blood ...
Noémie Vanacker, Richard Blouin, Céline Ster, Pierre Lacasse   +3 more
doaj   +1 more source